Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease

Amylin, a pancreatic peptide, and amyloid-beta peptides (Aβ), a major component of Alzheimer's disease (AD) brain, share similar β-sheet secondary structures, but it is not known whether pancreatic amylin affects amyloid pathogenesis in the AD brain. Using AD mouse models, we investigated the e...

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Detalles Bibliográficos
Autores principales: Zhu, H, Wang, X, Wallack, M, Li, H, Carreras, I, Dedeoglu, A, Hur, J-Y, Zheng, H, Fine, R, Mwamburi, M, Sun, X, Kowall, N, Stern, R A, Qiu, W Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161670/
https://www.ncbi.nlm.nih.gov/pubmed/24614496
http://dx.doi.org/10.1038/mp.2014.17

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