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Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea
PURPOSE: Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. This study was carried out to identify the common...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161682/ https://www.ncbi.nlm.nih.gov/pubmed/25228998 http://dx.doi.org/10.4168/aair.2014.6.5.415 |
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author | Jung, Jae-Woo Cho, Sang-Heon Kim, Kyu-Han Min, Kyung-Up Kang, Hye-Ryun |
author_facet | Jung, Jae-Woo Cho, Sang-Heon Kim, Kyu-Han Min, Kyung-Up Kang, Hye-Ryun |
author_sort | Jung, Jae-Woo |
collection | PubMed |
description | PURPOSE: Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. This study was carried out to identify the common causative drugs and clinical features of FDE in Korea. METHODS: We reviewed electronic medical records of all patients diagnosed with FDE from January 2000 to December 2010 at a tertiary hospital in Korea. RESULTS: A total of 134 cases were diagnosed as FDE. The mean age was 35.9 years (range, 0-82 years) and 69 (51.5%) of the patients were male. The mean duration from the first event to attending hospital was 1.9 years (range, 1-20 years). The mean number of recurrences was 2.6 (1-10), and 72.6% of patients sought medical care after experiencing symptoms twice or more. Four patients (3.1%) needed hospitalization. The most common sites were the upper extremities (47.7%), followed by the lower extremities, face, abdomen, chest, buttocks and perineum. Clear documentation on the causative drugs was available for 38 patients (28.4%), and among these, non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen accounted for 71.1% of cases, and antibiotics accounted for 15.8%. Eighty patients (59.7%) underwent active treatment for FDE, and topical steroids were most frequently prescribed (43.3%), with systemic steroids used in 11.2% of patients. CONCLUSIONS: NSAIDs and acetaminophen were the main causative agents of FDE, however, the causative agents were not assessed in 25% of patients. |
format | Online Article Text |
id | pubmed-4161682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-41616822014-09-16 Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea Jung, Jae-Woo Cho, Sang-Heon Kim, Kyu-Han Min, Kyung-Up Kang, Hye-Ryun Allergy Asthma Immunol Res Original Article PURPOSE: Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. This study was carried out to identify the common causative drugs and clinical features of FDE in Korea. METHODS: We reviewed electronic medical records of all patients diagnosed with FDE from January 2000 to December 2010 at a tertiary hospital in Korea. RESULTS: A total of 134 cases were diagnosed as FDE. The mean age was 35.9 years (range, 0-82 years) and 69 (51.5%) of the patients were male. The mean duration from the first event to attending hospital was 1.9 years (range, 1-20 years). The mean number of recurrences was 2.6 (1-10), and 72.6% of patients sought medical care after experiencing symptoms twice or more. Four patients (3.1%) needed hospitalization. The most common sites were the upper extremities (47.7%), followed by the lower extremities, face, abdomen, chest, buttocks and perineum. Clear documentation on the causative drugs was available for 38 patients (28.4%), and among these, non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen accounted for 71.1% of cases, and antibiotics accounted for 15.8%. Eighty patients (59.7%) underwent active treatment for FDE, and topical steroids were most frequently prescribed (43.3%), with systemic steroids used in 11.2% of patients. CONCLUSIONS: NSAIDs and acetaminophen were the main causative agents of FDE, however, the causative agents were not assessed in 25% of patients. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2014-09 2014-03-26 /pmc/articles/PMC4161682/ /pubmed/25228998 http://dx.doi.org/10.4168/aair.2014.6.5.415 Text en Copyright © 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jung, Jae-Woo Cho, Sang-Heon Kim, Kyu-Han Min, Kyung-Up Kang, Hye-Ryun Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title | Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title_full | Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title_fullStr | Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title_full_unstemmed | Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title_short | Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea |
title_sort | clinical features of fixed drug eruption at a tertiary hospital in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161682/ https://www.ncbi.nlm.nih.gov/pubmed/25228998 http://dx.doi.org/10.4168/aair.2014.6.5.415 |
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