Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

BACKGROUND: Gamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, the underlying mechanism of CS-6 involved in anti-tumor activity remains poorly understood. METHODS: The biological functions...

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Detalles Bibliográficos
Autores principales: Yu, Zhenlong, Guo, Wei, Ma, Xiaochi, Zhang, Baojing, Dong, Peipei, Huang, Lin, Wang, Xiuli, Wang, Chao, Huo, Xiaokui, Yu, Wendan, Yi, Canhui, Xiao, Yao, Yang, Wenjing, Qin, Yu, Yuan, Yuhui, Meng, Songshu, Liu, Quentin, Deng, Wuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161895/
https://www.ncbi.nlm.nih.gov/pubmed/25175164
http://dx.doi.org/10.1186/1476-4598-13-203

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