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Intratumoral heterogeneity impacts the response to anti-neu antibody therapy

BACKGROUND: Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new anti-HER2/neu antibody resistant and metastatic mouse breast carcinoma cell line,...

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Detalles Bibliográficos
Autores principales:	Song, Hyunkeun, Kim, Tae Oh, Ma, Sun Young, Park, Jin-Hee, Choi, Jae-Hyug, Kim, Jin-Ho, Kang, Mi Seon, Bae, Sang Kyun, Kim, Ki Hyaung, Kim, Tae Hyun, Seo, Su-Kil, Choi, Il Whan, Song, Geun Am, Mortenson, Eric D, Fu, Yang-Xin, Park, SaeGwang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161915/ https://www.ncbi.nlm.nih.gov/pubmed/25179116 http://dx.doi.org/10.1186/1471-2407-14-647

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