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Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats
The effects of seven nanomaterials (four amorphous silicon dioxides with or without surface functionalization, two surface-functionalized zirconium dioxides, and barium sulfate) upon 28-day oral exposure to male or female rats were investigated. The studies were performed as limit tests in accordanc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161931/ https://www.ncbi.nlm.nih.gov/pubmed/25164825 http://dx.doi.org/10.1007/s00204-014-1337-0 |
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author | Buesen, Roland Landsiedel, Robert Sauer, Ursula G. Wohlleben, Wendel Groeters, Sibylle Strauss, Volker Kamp, Hennicke van Ravenzwaay, Bennard |
author_facet | Buesen, Roland Landsiedel, Robert Sauer, Ursula G. Wohlleben, Wendel Groeters, Sibylle Strauss, Volker Kamp, Hennicke van Ravenzwaay, Bennard |
author_sort | Buesen, Roland |
collection | PubMed |
description | The effects of seven nanomaterials (four amorphous silicon dioxides with or without surface functionalization, two surface-functionalized zirconium dioxides, and barium sulfate) upon 28-day oral exposure to male or female rats were investigated. The studies were performed as limit tests in accordance with OECD Test Guideline 407 applying 1,000 mg test substance/kg body weight/day. Additionally, the acute phase proteins haptoglobin and α2-macroglobulin as well as cardiac troponin I were determined, and metabolome analysis was performed in plasma samples. There were no test substance-related adverse effects for any of the seven nanomaterials. Moreover, metabolomics changes were below the threshold of effects. Since test substance organ burden was not analyzed, it was not possible to establish whether the lack of findings related to the absence of systemic exposure of the tested nanomaterials or if the substances are devoid of any potential for toxicity. The few published subacute oral or short-term inhalation studies investigating comparable nanomaterials (SiO(2), ZrO(2), and BaSO(4)) also do not report the occurrence of pronounced treatment-related findings. Overall, the results of the present survey provide a first indication that the tested nanomaterials neither cause local nor systemic effects upon subacute oral administration under the selected experimental conditions. Further investigations should aim at elucidating the extent of gastrointestinal absorption of surface-functionalized nanomaterials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00204-014-1337-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4161931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-41619312014-09-12 Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats Buesen, Roland Landsiedel, Robert Sauer, Ursula G. Wohlleben, Wendel Groeters, Sibylle Strauss, Volker Kamp, Hennicke van Ravenzwaay, Bennard Arch Toxicol Nanotoxicology The effects of seven nanomaterials (four amorphous silicon dioxides with or without surface functionalization, two surface-functionalized zirconium dioxides, and barium sulfate) upon 28-day oral exposure to male or female rats were investigated. The studies were performed as limit tests in accordance with OECD Test Guideline 407 applying 1,000 mg test substance/kg body weight/day. Additionally, the acute phase proteins haptoglobin and α2-macroglobulin as well as cardiac troponin I were determined, and metabolome analysis was performed in plasma samples. There were no test substance-related adverse effects for any of the seven nanomaterials. Moreover, metabolomics changes were below the threshold of effects. Since test substance organ burden was not analyzed, it was not possible to establish whether the lack of findings related to the absence of systemic exposure of the tested nanomaterials or if the substances are devoid of any potential for toxicity. The few published subacute oral or short-term inhalation studies investigating comparable nanomaterials (SiO(2), ZrO(2), and BaSO(4)) also do not report the occurrence of pronounced treatment-related findings. Overall, the results of the present survey provide a first indication that the tested nanomaterials neither cause local nor systemic effects upon subacute oral administration under the selected experimental conditions. Further investigations should aim at elucidating the extent of gastrointestinal absorption of surface-functionalized nanomaterials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00204-014-1337-0) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-08-28 2014 /pmc/articles/PMC4161931/ /pubmed/25164825 http://dx.doi.org/10.1007/s00204-014-1337-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Nanotoxicology Buesen, Roland Landsiedel, Robert Sauer, Ursula G. Wohlleben, Wendel Groeters, Sibylle Strauss, Volker Kamp, Hennicke van Ravenzwaay, Bennard Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title | Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title_full | Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title_fullStr | Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title_full_unstemmed | Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title_short | Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
title_sort | effects of sio(2), zro(2), and baso(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats |
topic | Nanotoxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161931/ https://www.ncbi.nlm.nih.gov/pubmed/25164825 http://dx.doi.org/10.1007/s00204-014-1337-0 |
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