A Neurostimulant para-Chloroamphetamine Inhibits the Arginylation Branch of the N-end Rule Pathway

In the arginylation branch of the N-end rule pathway, unacetylated N-terminal destabilizing residues function as essential determinants of protein degradation signals (N-degron). Here, we show that a neurostimulant, para-chloroamphetamine (PCA), specifically inhibits the Arg/N-end rule pathway, dela...

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Detalles Bibliográficos
Autores principales: Jiang, Yanxialei, Choi, Won Hoon, Lee, Jung Hoon, Han, Dong Hoon, Kim, Ji Hyeon, Chung, Young-Shin, Kim, Se Hyun, Lee, Min Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161967/
https://www.ncbi.nlm.nih.gov/pubmed/25212999
http://dx.doi.org/10.1038/srep06344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161967/
https://www.ncbi.nlm.nih.gov/pubmed/25212999
http://dx.doi.org/10.1038/srep06344

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