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Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy

AIM: Pregnancy in women with epilepsy (WWE) who are on anti-epileptic drugs (AEDs) has two- to three-fold increased risk of fetal malformations. AEDs are mostly metabolized by Cyp2C9, Cyp2C19 and Cyp3A4 and transported by ABCB1. Patients on AED therapy can have folate deficiency. We hypothesize that...

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Detalles Bibliográficos
Autores principales:	Jose, Manna, Banerjee, Moinak, Mathew, Anila, Bharadwaj, Tashi, Vijayan, Neetha, Thomas, Sanjeev V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162009/ https://www.ncbi.nlm.nih.gov/pubmed/25221392 http://dx.doi.org/10.4103/0972-2327.138475

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