Cargando…
Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting
BACKGROUND: Fatigue contributes significantly to the morbidity and affects the quality of life adversely in Guillain-Barre Syndrome (GBS). OBJECTIVE: To determine the prevalence of fatigue in GBS in neurological rehabilitation setting and to study its clinical correlates. MATERIALS AND METHODS: We p...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162023/ https://www.ncbi.nlm.nih.gov/pubmed/25221406 http://dx.doi.org/10.4103/0972-2327.138521 |
_version_ | 1782334639052947456 |
---|---|
author | Ranjani, Prajna Khanna, Meeka Gupta, Anupam Nagappa, Madhu Taly, Arun B Haldar, Partha |
author_facet | Ranjani, Prajna Khanna, Meeka Gupta, Anupam Nagappa, Madhu Taly, Arun B Haldar, Partha |
author_sort | Ranjani, Prajna |
collection | PubMed |
description | BACKGROUND: Fatigue contributes significantly to the morbidity and affects the quality of life adversely in Guillain-Barre Syndrome (GBS). OBJECTIVE: To determine the prevalence of fatigue in GBS in neurological rehabilitation setting and to study its clinical correlates. MATERIALS AND METHODS: We performed secondary analysis of data of patients with GBS admitted in neurological rehabilitation ward of a tertiary care centre, recorded at both admission and discharge. Assessment of fatigue was done by Fatigue Severity Scale (FSS), disability-status by Hughe's Disability Scale (HDS), functional-status by Barthel Index, anxiety/depression by Hospital Anxiety Depression Scale, sleep disturbances by Pittsburgh Sleep Quality Index and muscle weakness by Medical Research Council sum scores. RESULTS: A total of 90 patients (62 men) with mean age 34 years (95% CI 32.2, 37.7) were included. Median duration of, stay at neurological rehabilitation ward was 30 days, while that of symptoms was 18.5 days. Presence of fatigue at admission (FSS ≥ 4 in 39% patients) was associated with ventilator requirement (P = 0.021) and neuropathic pain (P = 0.03). Presence of fatigue at discharge (FSS ≥ 4 in 12% patients) was associated with disability- HDS (≥3) (P = 0.008), presence of anxiety (P = 0.042) and duration of stay at rehabilitation ward (P = 0.02). Fatigue did not correlate with age, gender, antecedent illness, muscle weakness, depression and sleep disturbances. CONCLUSION: Fatigue is prevalent in GBS during early recovery phase of illness. Despite motor recovery fatigue may persist. Knowledge about fatigue as burden of disease in these patients will improve patient care. |
format | Online Article Text |
id | pubmed-4162023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41620232014-09-14 Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting Ranjani, Prajna Khanna, Meeka Gupta, Anupam Nagappa, Madhu Taly, Arun B Haldar, Partha Ann Indian Acad Neurol Original Article BACKGROUND: Fatigue contributes significantly to the morbidity and affects the quality of life adversely in Guillain-Barre Syndrome (GBS). OBJECTIVE: To determine the prevalence of fatigue in GBS in neurological rehabilitation setting and to study its clinical correlates. MATERIALS AND METHODS: We performed secondary analysis of data of patients with GBS admitted in neurological rehabilitation ward of a tertiary care centre, recorded at both admission and discharge. Assessment of fatigue was done by Fatigue Severity Scale (FSS), disability-status by Hughe's Disability Scale (HDS), functional-status by Barthel Index, anxiety/depression by Hospital Anxiety Depression Scale, sleep disturbances by Pittsburgh Sleep Quality Index and muscle weakness by Medical Research Council sum scores. RESULTS: A total of 90 patients (62 men) with mean age 34 years (95% CI 32.2, 37.7) were included. Median duration of, stay at neurological rehabilitation ward was 30 days, while that of symptoms was 18.5 days. Presence of fatigue at admission (FSS ≥ 4 in 39% patients) was associated with ventilator requirement (P = 0.021) and neuropathic pain (P = 0.03). Presence of fatigue at discharge (FSS ≥ 4 in 12% patients) was associated with disability- HDS (≥3) (P = 0.008), presence of anxiety (P = 0.042) and duration of stay at rehabilitation ward (P = 0.02). Fatigue did not correlate with age, gender, antecedent illness, muscle weakness, depression and sleep disturbances. CONCLUSION: Fatigue is prevalent in GBS during early recovery phase of illness. Despite motor recovery fatigue may persist. Knowledge about fatigue as burden of disease in these patients will improve patient care. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4162023/ /pubmed/25221406 http://dx.doi.org/10.4103/0972-2327.138521 Text en Copyright: © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ranjani, Prajna Khanna, Meeka Gupta, Anupam Nagappa, Madhu Taly, Arun B Haldar, Partha Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title | Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title_full | Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title_fullStr | Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title_full_unstemmed | Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title_short | Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting |
title_sort | prevalence of fatigue in guillain-barre syndrome in neurological rehabilitation setting |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162023/ https://www.ncbi.nlm.nih.gov/pubmed/25221406 http://dx.doi.org/10.4103/0972-2327.138521 |
work_keys_str_mv | AT ranjaniprajna prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting AT khannameeka prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting AT guptaanupam prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting AT nagappamadhu prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting AT talyarunb prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting AT haldarpartha prevalenceoffatigueinguillainbarresyndromeinneurologicalrehabilitationsetting |