Cargando…
Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis
BACKGROUND: This study was done to evaluate the effect of itraconazole on clinical symptoms and radiologic findings in patients with chronic rhinosinusitis and nasal polyposis after surgery. MATERIALS AND METHODS: In a clinical trial which was conducted in Alzahra and Kashani hospitals, from Novembe...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162036/ https://www.ncbi.nlm.nih.gov/pubmed/25221765 http://dx.doi.org/10.4103/2277-9175.139124 |
_version_ | 1782334642546802688 |
---|---|
author | Hashemi, Mostafa Fereidani, Akram Berjis, Nezamoddin Okhovat, Sayyed Ahmad Reza Eshaghain, Afrooz |
author_facet | Hashemi, Mostafa Fereidani, Akram Berjis, Nezamoddin Okhovat, Sayyed Ahmad Reza Eshaghain, Afrooz |
author_sort | Hashemi, Mostafa |
collection | PubMed |
description | BACKGROUND: This study was done to evaluate the effect of itraconazole on clinical symptoms and radiologic findings in patients with chronic rhinosinusitis and nasal polyposis after surgery. MATERIALS AND METHODS: In a clinical trial which was conducted in Alzahra and Kashani hospitals, from November 2011 to December 2012, 22 patients with recurrent postsurgical chronic sinusitis and polyposis entered the study. At the start of the study demographic data, subjective clinical symptoms (severity of rhinorrhea, nasal obstruction, hyposmia, and dyspnea), quality of life (QoL) by sinonasal outcome test-20 (SNOT-20), serum immunoglobulin E (IgE), and score of computed tomography (CT) scan (by Lund-Mackay) were recorded. Itraconazole (100 mg, twice per day) prescribed for 3 months and patients were followed in the 1(st), 3(rd), and 6(th) months. Liver enzyme tests and side effects were evaluated monthly. RESULTS: Severity of rhinorrhea, nasal obstruction, hyposmia, dyspnea, and QoL (by SNOT-20) improved during 3 months of treatment. Serum IgE was 265 (±277) at the start of the study, and decrease to 193 (±183) after 3 month. After 3 month, Lund-Mackay score of CT scan lowered from 19 (±4) to 15 (±6) (P < 0.05). At the 6(th) month, severity of clinical symptoms except dyspnea and QoL were better than first evaluation. CONCLUSION: This study showed the beneficial effect of 3-month itraconazole treatment on clinical symptoms and radiologic findings and QoL in patients with recurrent postsurgical chronic rhinosinusitis and nasal polyposis. |
format | Online Article Text |
id | pubmed-4162036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41620362014-09-14 Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis Hashemi, Mostafa Fereidani, Akram Berjis, Nezamoddin Okhovat, Sayyed Ahmad Reza Eshaghain, Afrooz Adv Biomed Res Original Article BACKGROUND: This study was done to evaluate the effect of itraconazole on clinical symptoms and radiologic findings in patients with chronic rhinosinusitis and nasal polyposis after surgery. MATERIALS AND METHODS: In a clinical trial which was conducted in Alzahra and Kashani hospitals, from November 2011 to December 2012, 22 patients with recurrent postsurgical chronic sinusitis and polyposis entered the study. At the start of the study demographic data, subjective clinical symptoms (severity of rhinorrhea, nasal obstruction, hyposmia, and dyspnea), quality of life (QoL) by sinonasal outcome test-20 (SNOT-20), serum immunoglobulin E (IgE), and score of computed tomography (CT) scan (by Lund-Mackay) were recorded. Itraconazole (100 mg, twice per day) prescribed for 3 months and patients were followed in the 1(st), 3(rd), and 6(th) months. Liver enzyme tests and side effects were evaluated monthly. RESULTS: Severity of rhinorrhea, nasal obstruction, hyposmia, dyspnea, and QoL (by SNOT-20) improved during 3 months of treatment. Serum IgE was 265 (±277) at the start of the study, and decrease to 193 (±183) after 3 month. After 3 month, Lund-Mackay score of CT scan lowered from 19 (±4) to 15 (±6) (P < 0.05). At the 6(th) month, severity of clinical symptoms except dyspnea and QoL were better than first evaluation. CONCLUSION: This study showed the beneficial effect of 3-month itraconazole treatment on clinical symptoms and radiologic findings and QoL in patients with recurrent postsurgical chronic rhinosinusitis and nasal polyposis. Medknow Publications & Media Pvt Ltd 2014-08-19 /pmc/articles/PMC4162036/ /pubmed/25221765 http://dx.doi.org/10.4103/2277-9175.139124 Text en Copyright: © 2014 Hashemi. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Hashemi, Mostafa Fereidani, Akram Berjis, Nezamoddin Okhovat, Sayyed Ahmad Reza Eshaghain, Afrooz Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title | Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title_full | Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title_fullStr | Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title_full_unstemmed | Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title_short | Effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
title_sort | effectiveness of itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162036/ https://www.ncbi.nlm.nih.gov/pubmed/25221765 http://dx.doi.org/10.4103/2277-9175.139124 |
work_keys_str_mv | AT hashemimostafa effectivenessofitraconazoleonclinicalsymptomsandradiologicfindingsinpatientswithrecurrentchronicrhinosinusitisandnasalpolyposis AT fereidaniakram effectivenessofitraconazoleonclinicalsymptomsandradiologicfindingsinpatientswithrecurrentchronicrhinosinusitisandnasalpolyposis AT berjisnezamoddin effectivenessofitraconazoleonclinicalsymptomsandradiologicfindingsinpatientswithrecurrentchronicrhinosinusitisandnasalpolyposis AT okhovatsayyedahmadreza effectivenessofitraconazoleonclinicalsymptomsandradiologicfindingsinpatientswithrecurrentchronicrhinosinusitisandnasalpolyposis AT eshaghainafrooz effectivenessofitraconazoleonclinicalsymptomsandradiologicfindingsinpatientswithrecurrentchronicrhinosinusitisandnasalpolyposis |