Cargando…

Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer

The fusion between ERG coding sequences and the TMPRSS2 promoter is the most prevalent in prostate cancer (CaP). The presence of two main types of TMPRSS2-ERG fusion transcripts in CaP specimens, Type I and Type II, prompted us to hypothesize that the cumulative actions of different ERG variants may...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rastogi, Anshu, Tan, Shyh-Han, Mohamed, Ahmed A., Chen, Yongmei, Hu, Ying, Petrovics, Gyorgy, Sreenath, Taduru, Kagan, Jacob, Srivastava, Sudhir, McLeod, David G., Sesterhenn, Isabell A., Srivastava, Shiv, Dobi, Albert, Srinivasan, Alagarsamy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162137/ https://www.ncbi.nlm.nih.gov/pubmed/25221645

Ejemplares similares

Oncogenic activation of ERG: A predominant mechanism in prostate cancer
por: Sreenath, Taduru L, et al.
Publicado: (2011)

Quantitative Expression of TMPRSS2 Transcript in Prostate Tumor Cells Reflects TMPRSS2-ERG Fusion Status
por: Mwamukonda, Kuwong, et al.
Publicado: (2009)

Autoantibodies against oncogenic ERG protein in prostate cancer: potential use in diagnosis and prognosis in a panel with C-MYC, AMACR and HERV-K Gag
por: Rastogi, Anshu, et al.
Publicado: (2016)

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence
por: Yan, Wusheng, et al.
Publicado: (2019)

Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1
por: Kumar, Parameet, et al.
Publicado: (2016)

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
por: Thangapazham, Rajesh, et al.
Publicado: (2014)

Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer
por: Kohaar, Indu, et al.
Publicado: (2020)

Low Frequency of the ERG Oncogene Alterations in Prostate Cancer Patients from India
por: Rawal, Sudhir, et al.
Publicado: (2013)

Ets Family Protein, Erg Expression in Developing and Adult Mouse Tissues by a Highly Specific Monoclonal Antibody
por: Mohamed, Ahmed A., et al.
Publicado: (2010)

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN
por: Li, Hua, et al.
Publicado: (2015)

ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification
por: Furusato, B, et al.
Publicado: (2010)

Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods
por: He, Jintang, et al.
Publicado: (2015)

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer
por: Sharad, Shashwat, et al.
Publicado: (2014)

Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer
por: Sharad, Shashwat, et al.
Publicado: (2019)

ERG Tumor Type is Less Frequent in High Grade and High Stage Prostate Cancers of Chinese Men
por: Baohong, Jiang, et al.
Publicado: (2019)

Prostate cancer marker panel with single cell sensitivity in urine
por: Nickens, Kristen P., et al.
Publicado: (2015)

ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development
por: Sreenath, Taduru L., et al.
Publicado: (2017)

Erratum: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development
por: Sreenath, Taduru L., et al.
Publicado: (2017)

Genetic and Molecular Differences in Prostate Carcinogenesis between African American and Caucasian American Men
por: Farrell, James, et al.
Publicado: (2013)

Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
por: Gesztes, William, et al.
Publicado: (2022)

Prostate Cancer Genomics: Recent Advances and the Prevailing Underrepresentation from Racial and Ethnic Minorities
por: Tan, Shyh-Han, et al.
Publicado: (2018)

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer
por: Kiebish, Michael A., et al.
Publicado: (2020)

PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer
por: Sharad, Shashwat, et al.
Publicado: (2020)

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer
por: Xiao, Qingyu, et al.
Publicado: (2018)

Long noncoding RNA-mediated activation of androgen receptor in prostate cancer
por: Petrovics, Gyorgy, et al.
Publicado: (2014)

Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression
por: Gao, Yuqian, et al.
Publicado: (2020)

A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men
por: Petrovics, Gyorgy, et al.
Publicado: (2015)

Reconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate Tumors
por: Dubovenko, Alexey, et al.
Publicado: (2015)

Prostate cancer gene expression signature of patients with high body mass index
por: Sharad, Shashwat, et al.
Publicado: (2010)

A Rich Array of Prostate Cancer Molecular Biomarkers: Opportunities and Challenges
por: Kohaar, Indu, et al.
Publicado: (2019)

TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation
por: Casey, Orla M., et al.
Publicado: (2012)

Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers
por: Sharad, Shashwat, et al.
Publicado: (2021)

New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU-6 Salt Derivatives
por: Eldhose, Binil, et al.
Publicado: (2021)

5′ UTR Control of Native ERG and of Tmprss2:ERG Variants Activity in Prostate Cancer
por: Zammarchi, Francesca, et al.
Publicado: (2013)

Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
por: Kohaar, Indu, et al.
Publicado: (2022)

Significance of the TMPRSS2:ERG gene fusion in prostate cancer
por: Wang, Zhu, et al.
Publicado: (2017)

Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer
por: Nam, R K, et al.
Publicado: (2007)

TMPRSS2-ERG fusion promotes prostate cancer metastases in bone
por: Deplus, Rachel, et al.
Publicado: (2016)

Molecular Composition of Genomic TMPRSS2-ERG Rearrangements in Prostate Cancer
por: Krumbholz, Manuela, et al.
Publicado: (2019)

Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence
por: Kobelyatskaya, Anastasiya A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p5v1r0e4lmhpnagi7ktchckj0j