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LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

PURPOSE OF REVIEW: To review the profile of ETC-1002, as shown in preclinical and clinical studies, including LDL-cholesterol (LDL-C)-lowering activity and beneficial effects on other cardiometabolic risk markers as they relate to the inhibition of adenosine triphosphate-citrate lyase and the activa...

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Detalles Bibliográficos
Autores principales:	Filippov, Sergey, Pinkosky, Stephen L., Newton, Roger S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2014
Materias:	HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162331/ https://www.ncbi.nlm.nih.gov/pubmed/24978142 http://dx.doi.org/10.1097/MOL.0000000000000091

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