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The serotonin receptor 7 and the structural plasticity of brain circuits

Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotransmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian...

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Autores principales: Volpicelli, Floriana, Speranza, Luisa, di Porzio, Umberto, Crispino, Marianna, Perrone-Capano, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162376/
https://www.ncbi.nlm.nih.gov/pubmed/25309369
http://dx.doi.org/10.3389/fnbeh.2014.00318
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author Volpicelli, Floriana
Speranza, Luisa
di Porzio, Umberto
Crispino, Marianna
Perrone-Capano, Carla
author_facet Volpicelli, Floriana
Speranza, Luisa
di Porzio, Umberto
Crispino, Marianna
Perrone-Capano, Carla
author_sort Volpicelli, Floriana
collection PubMed
description Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotransmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian brain 5-HT innervation is virtually ubiquitous and the diversity and specificity of its signaling and function arise from at least 20 different receptors, grouped in 7 classes. Here we will focus on the role 5-HT7 receptor (5-HT7R) in the correct establishment of neuronal cytoarchitecture during development, as also suggested by its involvement in several neurodevelopmental disorders. The emerging picture shows that this receptor is a key player contributing not only to shape brain networks during development but also to remodel neuronal wiring in the mature brain, thus controlling cognitive and emotional responses. The activation of 5-HT7R might be one of the mechanisms underlying the ability of the CNS to respond to different stimuli by modulation of its circuit configuration.
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spelling pubmed-41623762014-10-10 The serotonin receptor 7 and the structural plasticity of brain circuits Volpicelli, Floriana Speranza, Luisa di Porzio, Umberto Crispino, Marianna Perrone-Capano, Carla Front Behav Neurosci Neuroscience Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotransmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian brain 5-HT innervation is virtually ubiquitous and the diversity and specificity of its signaling and function arise from at least 20 different receptors, grouped in 7 classes. Here we will focus on the role 5-HT7 receptor (5-HT7R) in the correct establishment of neuronal cytoarchitecture during development, as also suggested by its involvement in several neurodevelopmental disorders. The emerging picture shows that this receptor is a key player contributing not only to shape brain networks during development but also to remodel neuronal wiring in the mature brain, thus controlling cognitive and emotional responses. The activation of 5-HT7R might be one of the mechanisms underlying the ability of the CNS to respond to different stimuli by modulation of its circuit configuration. Frontiers Media S.A. 2014-09-12 /pmc/articles/PMC4162376/ /pubmed/25309369 http://dx.doi.org/10.3389/fnbeh.2014.00318 Text en Copyright © 2014 Volpicelli, Speranza, di Porzio, Crispino and Perrone-Capano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Volpicelli, Floriana
Speranza, Luisa
di Porzio, Umberto
Crispino, Marianna
Perrone-Capano, Carla
The serotonin receptor 7 and the structural plasticity of brain circuits
title The serotonin receptor 7 and the structural plasticity of brain circuits
title_full The serotonin receptor 7 and the structural plasticity of brain circuits
title_fullStr The serotonin receptor 7 and the structural plasticity of brain circuits
title_full_unstemmed The serotonin receptor 7 and the structural plasticity of brain circuits
title_short The serotonin receptor 7 and the structural plasticity of brain circuits
title_sort serotonin receptor 7 and the structural plasticity of brain circuits
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162376/
https://www.ncbi.nlm.nih.gov/pubmed/25309369
http://dx.doi.org/10.3389/fnbeh.2014.00318
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