JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination

Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear...

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Detalles Bibliográficos
Autores principales: Komulainen, Emilia, Zdrojewska, Justyna, Freemantle, Erika, Mohammad, Hasan, Kulesskaya, Natalia, Deshpande, Prasannakumar, Marchisella, Francesca, Mysore, Raghavendra, Hollos, Patrik, Michelsen, Kimmo A., Mågard, Mats, Rauvala, Heikki, James, Peter, Coffey, Eleanor T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162472/
https://www.ncbi.nlm.nih.gov/pubmed/25309320
http://dx.doi.org/10.3389/fncel.2014.00272

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