The effect of arginine glutamate on the stability of monoclonal antibodies in solution

Finding excipients which mitigate protein self-association and aggregation is an important task during formulation. Here, the effect of an equimolar mixture of l-Arg and l-Glu (Arg·Glu) on colloidal and conformational stability of four monoclonal antibodies (mAb1–mAb4) at different pH is explored, w...

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Detalles Bibliográficos
Autores principales: Kheddo, Priscilla, Tracka, Malgorzata, Armer, Jonathan, Dearman, Rebecca J., Uddin, Shahid, van der Walle, Christopher F., Golovanov, Alexander P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162492/
https://www.ncbi.nlm.nih.gov/pubmed/24992318
http://dx.doi.org/10.1016/j.ijpharm.2014.06.053

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