Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer

PURPOSE: Unresectable chest wall recurrences of breast cancer (CWR) in heavily pretreated patients are especially difficult to treat. We hypothesised that thermally enhanced drug delivery using low temperature liposomal doxorubicin (LTLD), given with mild local hyperthermia (MLHT), will be safe and...

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Detalles Bibliográficos
Autores principales: Zagar, Timothy M., Vujaskovic, Zeljko, Formenti, Silvia, Rugo, Hope, Muggia, Franco, O’Connor, Brigid, Myerson, Robert, Stauffer, Paul, Hsu, I-Chow, Diederich, Chris, Straube, William, Boss, Mary-Keara, Boico, Alina, Craciunescu, Oana, Maccarini, Paolo, Needham, David, Borys, Nicholas, Blackwell, Kimberly L., Dewhirst, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa UK Ltd. 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162656/
https://www.ncbi.nlm.nih.gov/pubmed/25144817
http://dx.doi.org/10.3109/02656736.2014.936049

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