Cargando…
Asthma in the elderly: a study of the role of vitamin D
BACKGROUND: Asthma in the elderly is poorly understood and vitamin D deficiency and insufficiency are very common in older individuals. We studied the role of vitamin D in elderly asthmatics. METHODS: Asthmatics subjects, age 65 and older, were followed every 4 weeks for 12 weeks in the late fall an...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162927/ https://www.ncbi.nlm.nih.gov/pubmed/25221606 http://dx.doi.org/10.1186/1710-1492-10-48 |
_version_ | 1782334725555224576 |
---|---|
author | Columbo, Michele Panettieri, Reynold A Rohr, Albert S |
author_facet | Columbo, Michele Panettieri, Reynold A Rohr, Albert S |
author_sort | Columbo, Michele |
collection | PubMed |
description | BACKGROUND: Asthma in the elderly is poorly understood and vitamin D deficiency and insufficiency are very common in older individuals. We studied the role of vitamin D in elderly asthmatics. METHODS: Asthmatics subjects, age 65 and older, were followed every 4 weeks for 12 weeks in the late fall and winter. During the study period they took 2,000 I.U. vitamin D3 daily. Serum 25-Hydroxyvitamin D and calcium were measured at baseline and study end. RESULTS: Twenty nine percent of subjects were deficient and 50% insufficient in serum vitamin D at baseline. Serum vitamin D increased from 24.3±9.2 ng/ml (60.7±23 nmol/L) to 34±7.1 ng/ml (84.9±17.7 nmol/L) at the end of the study (p<0.001), whereas calcium was unchanged. We found no significant association between vitamin D and subjects' demographics. Vitamin D was similar in men and women. There was no association between serum vitamin D and inhaled steroid dose. Vitamin D was significantly lower in subjects with uncontrolled asthma (Asthma Control Test, ACT≤19) compared to the ones with well controlled symptoms (p<0.05). In subjects with uncontrolled asthma at baseline, ACT scores increased significantly at the end of the study (p<0.04), but not at 4 and 8 weeks. Spirometric values remained unchanged throughout the study. CONCLUSIONS: Elderly asthmatics very commonly have vitamin D deficiency or insufficiency. Serum vitamin D levels were lower in subjects with uncontrolled asthma. In these subjects, vitamin D supplementation for 12 weeks led to improved ACT scores. Larger, randomized, placebo controlled studies are required to further evaluate whether vitamin D supplementation may improve asthma symptoms in this population. TRIAL REGISTRATION: ClinicalTrials.gov NCT01730976. |
format | Online Article Text |
id | pubmed-4162927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41629272014-09-14 Asthma in the elderly: a study of the role of vitamin D Columbo, Michele Panettieri, Reynold A Rohr, Albert S Allergy Asthma Clin Immunol Short Report BACKGROUND: Asthma in the elderly is poorly understood and vitamin D deficiency and insufficiency are very common in older individuals. We studied the role of vitamin D in elderly asthmatics. METHODS: Asthmatics subjects, age 65 and older, were followed every 4 weeks for 12 weeks in the late fall and winter. During the study period they took 2,000 I.U. vitamin D3 daily. Serum 25-Hydroxyvitamin D and calcium were measured at baseline and study end. RESULTS: Twenty nine percent of subjects were deficient and 50% insufficient in serum vitamin D at baseline. Serum vitamin D increased from 24.3±9.2 ng/ml (60.7±23 nmol/L) to 34±7.1 ng/ml (84.9±17.7 nmol/L) at the end of the study (p<0.001), whereas calcium was unchanged. We found no significant association between vitamin D and subjects' demographics. Vitamin D was similar in men and women. There was no association between serum vitamin D and inhaled steroid dose. Vitamin D was significantly lower in subjects with uncontrolled asthma (Asthma Control Test, ACT≤19) compared to the ones with well controlled symptoms (p<0.05). In subjects with uncontrolled asthma at baseline, ACT scores increased significantly at the end of the study (p<0.04), but not at 4 and 8 weeks. Spirometric values remained unchanged throughout the study. CONCLUSIONS: Elderly asthmatics very commonly have vitamin D deficiency or insufficiency. Serum vitamin D levels were lower in subjects with uncontrolled asthma. In these subjects, vitamin D supplementation for 12 weeks led to improved ACT scores. Larger, randomized, placebo controlled studies are required to further evaluate whether vitamin D supplementation may improve asthma symptoms in this population. TRIAL REGISTRATION: ClinicalTrials.gov NCT01730976. BioMed Central 2014-09-05 /pmc/articles/PMC4162927/ /pubmed/25221606 http://dx.doi.org/10.1186/1710-1492-10-48 Text en © Columbo et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Columbo, Michele Panettieri, Reynold A Rohr, Albert S Asthma in the elderly: a study of the role of vitamin D |
title | Asthma in the elderly: a study of the role of vitamin D |
title_full | Asthma in the elderly: a study of the role of vitamin D |
title_fullStr | Asthma in the elderly: a study of the role of vitamin D |
title_full_unstemmed | Asthma in the elderly: a study of the role of vitamin D |
title_short | Asthma in the elderly: a study of the role of vitamin D |
title_sort | asthma in the elderly: a study of the role of vitamin d |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162927/ https://www.ncbi.nlm.nih.gov/pubmed/25221606 http://dx.doi.org/10.1186/1710-1492-10-48 |
work_keys_str_mv | AT columbomichele asthmaintheelderlyastudyoftheroleofvitamind AT panettierireynolda asthmaintheelderlyastudyoftheroleofvitamind AT rohralberts asthmaintheelderlyastudyoftheroleofvitamind |