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The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients

PURPOSE: It is important for patients to complete the planned hormone therapy to reduce both the recurrence and mortality rates of hormone receptor-positive breast cancer. We investigated the rates and factors related to the early discontinuation of adjuvant hormone therapy at our institution. METHO...

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Autores principales: Taketani, Kenji, Tokunaga, Eriko, Yamashita, Nami, Tanaka, Kimihiro, Akiyoshi, Sayuri, Okada, Satoko, Ando, Koji, Kimura, Yasue, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Kusumoto, Tetsuya, Maehara, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162979/
https://www.ncbi.nlm.nih.gov/pubmed/24142101
http://dx.doi.org/10.1007/s00595-013-0762-7
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author Taketani, Kenji
Tokunaga, Eriko
Yamashita, Nami
Tanaka, Kimihiro
Akiyoshi, Sayuri
Okada, Satoko
Ando, Koji
Kimura, Yasue
Saeki, Hiroshi
Oki, Eiji
Morita, Masaru
Kusumoto, Tetsuya
Maehara, Yoshihiko
author_facet Taketani, Kenji
Tokunaga, Eriko
Yamashita, Nami
Tanaka, Kimihiro
Akiyoshi, Sayuri
Okada, Satoko
Ando, Koji
Kimura, Yasue
Saeki, Hiroshi
Oki, Eiji
Morita, Masaru
Kusumoto, Tetsuya
Maehara, Yoshihiko
author_sort Taketani, Kenji
collection PubMed
description PURPOSE: It is important for patients to complete the planned hormone therapy to reduce both the recurrence and mortality rates of hormone receptor-positive breast cancer. We investigated the rates and factors related to the early discontinuation of adjuvant hormone therapy at our institution. METHODS: We identified 145 females prescribed adjuvant hormone therapy who were followed up for longer than 5 years. The rate of completing the planned hormone therapy and factors related to early discontinuation were examined. The relapse-free survival rate was examined between the completion group and the discontinuation group. RESULTS: The completion rate was 90.6 %. The primary reason for discontinuing hormone therapy within 5 years was side effects, such as arthritic pain. The primary factor related to early discontinuation was a significantly younger age. The relapse-free survival rate was significantly lower in the discontinuation group (p = 0.025). CONCLUSIONS: More than 90 % of the patients completed the planned adjuvant hormone therapy, and early discontinuation was related to a shorter RFS. To improve the rate of the successful completion of adjuvant hormone therapy, it is important to provide supportive care to reduce the occurrence of side effects and to care for young females with a desire to become pregnant.
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spelling pubmed-41629792014-09-18 The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients Taketani, Kenji Tokunaga, Eriko Yamashita, Nami Tanaka, Kimihiro Akiyoshi, Sayuri Okada, Satoko Ando, Koji Kimura, Yasue Saeki, Hiroshi Oki, Eiji Morita, Masaru Kusumoto, Tetsuya Maehara, Yoshihiko Surg Today Original Article PURPOSE: It is important for patients to complete the planned hormone therapy to reduce both the recurrence and mortality rates of hormone receptor-positive breast cancer. We investigated the rates and factors related to the early discontinuation of adjuvant hormone therapy at our institution. METHODS: We identified 145 females prescribed adjuvant hormone therapy who were followed up for longer than 5 years. The rate of completing the planned hormone therapy and factors related to early discontinuation were examined. The relapse-free survival rate was examined between the completion group and the discontinuation group. RESULTS: The completion rate was 90.6 %. The primary reason for discontinuing hormone therapy within 5 years was side effects, such as arthritic pain. The primary factor related to early discontinuation was a significantly younger age. The relapse-free survival rate was significantly lower in the discontinuation group (p = 0.025). CONCLUSIONS: More than 90 % of the patients completed the planned adjuvant hormone therapy, and early discontinuation was related to a shorter RFS. To improve the rate of the successful completion of adjuvant hormone therapy, it is important to provide supportive care to reduce the occurrence of side effects and to care for young females with a desire to become pregnant. Springer Japan 2013-10-19 2014 /pmc/articles/PMC4162979/ /pubmed/24142101 http://dx.doi.org/10.1007/s00595-013-0762-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Taketani, Kenji
Tokunaga, Eriko
Yamashita, Nami
Tanaka, Kimihiro
Akiyoshi, Sayuri
Okada, Satoko
Ando, Koji
Kimura, Yasue
Saeki, Hiroshi
Oki, Eiji
Morita, Masaru
Kusumoto, Tetsuya
Maehara, Yoshihiko
The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title_full The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title_fullStr The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title_full_unstemmed The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title_short The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients
title_sort early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in japanese breast cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162979/
https://www.ncbi.nlm.nih.gov/pubmed/24142101
http://dx.doi.org/10.1007/s00595-013-0762-7
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