The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: Down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

The tobacco-related species Nicotiana benthamiana has recently emerged as a promising host for the manufacturing of protein therapeutics. However, the production of recombinant proteins in N. benthamiana is frequently hampered by undesired proteolysis. Here, we show that the expression of the human...

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Detalles Bibliográficos
Autores principales: Niemer, Melanie, Mehofer, Ulrich, Torres Acosta, Juan Antonio, Verdianz, Maria, Henkel, Theresa, Loos, Andreas, Strasser, Richard, Maresch, Daniel, Rademacher, Thomas, Steinkellner, Herta, Mach, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162989/
https://www.ncbi.nlm.nih.gov/pubmed/24478053
http://dx.doi.org/10.1002/biot.201300207

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