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CD160 isoforms and regulation of CD4 and CD8 T-cell responses

BACKGROUND: Coexpression of CD160 and PD-1 on HIV-specific CD8(+) T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and blocking this interaction with HVEM antibodies reverses T-cell exhaustion. As HVEM binds both inhibitory and activatory receptors,...

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Detalles Bibliográficos
Autores principales:	El-Far, Mohamed, Pellerin, Charles, Pilote, Louise, Fortin, Jean-Francois, Lessard, Ivan A D, Peretz, Yoav, Wardrop, Elizabeth, Salois, Patrick, Bethell, Richard C, Cordingley, Michael G, Kukolj, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163173/ https://www.ncbi.nlm.nih.gov/pubmed/25179432 http://dx.doi.org/10.1186/s12967-014-0217-y

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