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The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon
Background and Objective: The coronary slow flow phenomenon (CSFP) is a coronary artery disease with a benign course, but its pathological mechanisms are not yet fully understood.The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publicaitons
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163207/ https://www.ncbi.nlm.nih.gov/pubmed/25225502 http://dx.doi.org/10.12669/pjms.305.4935 |
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author | Soylu, Korhan Gulel, Okan Yucel, Huriye Yuksel, Serkan Aksan, Gokhan Soylu, Ayşegül İdil Demircan, Sabri Yılmaz, Özcan Sahin, Mahmut |
author_facet | Soylu, Korhan Gulel, Okan Yucel, Huriye Yuksel, Serkan Aksan, Gokhan Soylu, Ayşegül İdil Demircan, Sabri Yılmaz, Özcan Sahin, Mahmut |
author_sort | Soylu, Korhan |
collection | PubMed |
description | Background and Objective: The coronary slow flow phenomenon (CSFP) is a coronary artery disease with a benign course, but its pathological mechanisms are not yet fully understood.The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and the relationship of this with coronary flow rates. Methods: Selective coronary angiographies of 3368 patients were analyzed to assess Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) values. Seventy eight of them had CSFP, and their demographic and laboratory findings were compared with 61 patients with normal coronary flow. Results: Patients’ demographic characteristics were similar in both groups. Mean corrected TFC (cTFC) values were significantly elevated in CSFP patients (p<0.001). Furthermore, hematocrit and hemoglobin values, and eosinophil and basophil counts of the CSFP patients were significantly elevated compared to the values obtained in the control group (p=0.005, p=0.047, p=0.001 and p=0.002, respectively). The increase observed in hematocrit and eosinophil levels showed significant correlations with increased TFC values (r=0.288 and r=0.217, respectively). Conclusion: Significant changes have been observed in the cellular composition of blood in patients diagnosed with CSFP as compared to the patients with normal coronary blood flow. The increases in hematocrit levels and in the eosinophil and basophil counts may have direct or indirect effects on the rate of coronary blood flow. |
format | Online Article Text |
id | pubmed-4163207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Professional Medical Publicaitons |
record_format | MEDLINE/PubMed |
spelling | pubmed-41632072014-09-15 The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon Soylu, Korhan Gulel, Okan Yucel, Huriye Yuksel, Serkan Aksan, Gokhan Soylu, Ayşegül İdil Demircan, Sabri Yılmaz, Özcan Sahin, Mahmut Pak J Med Sci Original Article Background and Objective: The coronary slow flow phenomenon (CSFP) is a coronary artery disease with a benign course, but its pathological mechanisms are not yet fully understood.The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and the relationship of this with coronary flow rates. Methods: Selective coronary angiographies of 3368 patients were analyzed to assess Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) values. Seventy eight of them had CSFP, and their demographic and laboratory findings were compared with 61 patients with normal coronary flow. Results: Patients’ demographic characteristics were similar in both groups. Mean corrected TFC (cTFC) values were significantly elevated in CSFP patients (p<0.001). Furthermore, hematocrit and hemoglobin values, and eosinophil and basophil counts of the CSFP patients were significantly elevated compared to the values obtained in the control group (p=0.005, p=0.047, p=0.001 and p=0.002, respectively). The increase observed in hematocrit and eosinophil levels showed significant correlations with increased TFC values (r=0.288 and r=0.217, respectively). Conclusion: Significant changes have been observed in the cellular composition of blood in patients diagnosed with CSFP as compared to the patients with normal coronary blood flow. The increases in hematocrit levels and in the eosinophil and basophil counts may have direct or indirect effects on the rate of coronary blood flow. Professional Medical Publicaitons 2014 /pmc/articles/PMC4163207/ /pubmed/25225502 http://dx.doi.org/10.12669/pjms.305.4935 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Soylu, Korhan Gulel, Okan Yucel, Huriye Yuksel, Serkan Aksan, Gokhan Soylu, Ayşegül İdil Demircan, Sabri Yılmaz, Özcan Sahin, Mahmut The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title | The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title_full | The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title_fullStr | The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title_full_unstemmed | The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title_short | The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
title_sort | effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163207/ https://www.ncbi.nlm.nih.gov/pubmed/25225502 http://dx.doi.org/10.12669/pjms.305.4935 |
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