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Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis

Background: Rabies is a fatal infectious disease and rabies post-exposure prophylaxis is the method of choice for prevention of human rabies. Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immuni...

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Autores principales: Fayaz, Ahmad, Simani, Susan, Fallahian, Vida, Eslamifar, Ali, Hazrati, Mahboob, Farahtaj, Firoozeh, Howaizi, Nader, Biglari, Peivand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163280/
https://www.ncbi.nlm.nih.gov/pubmed/25242991
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author Fayaz, Ahmad
Simani, Susan
Fallahian, Vida
Eslamifar, Ali
Hazrati, Mahboob
Farahtaj, Firoozeh
Howaizi, Nader
Biglari, Peivand
author_facet Fayaz, Ahmad
Simani, Susan
Fallahian, Vida
Eslamifar, Ali
Hazrati, Mahboob
Farahtaj, Firoozeh
Howaizi, Nader
Biglari, Peivand
author_sort Fayaz, Ahmad
collection PubMed
description Background: Rabies is a fatal infectious disease and rabies post-exposure prophylaxis is the method of choice for prevention of human rabies. Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immunized by purified Vero cell rabies vaccine (PVRV) and Human Rabies immunoglobulin (HRIG) serum. During the years of 2007-2010, six pregnant women by the age range of 22-35 years were admitted in treatment and prevention of rabies center in Pasture institute of Iran, in Tehran. Among them two cases were at first trimester, one at second trimester and three at third trimester of conception. The interval between biting with delivery was 5-265 days (mean 121 days). Conclusion: Results of immunoglobulin illustrate that levels of rabies antibody in maternal sera with the fetus are not equal and uniform but it is proved that baby will find efficient immunity as well with minimum protective level of 0.5 IU/ml in all cases except a newborn whom had been born just 5 days after the mother’s immunization and in a shorter time than the appropriate immunization of the mother who had received her second vaccination courses.
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spelling pubmed-41632802014-09-19 Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis Fayaz, Ahmad Simani, Susan Fallahian, Vida Eslamifar, Ali Hazrati, Mahboob Farahtaj, Firoozeh Howaizi, Nader Biglari, Peivand Iran J Reprod Med Case Series Background: Rabies is a fatal infectious disease and rabies post-exposure prophylaxis is the method of choice for prevention of human rabies. Case series: We report rabies antibody levels in cord blood and also in serum of pregnant women who were bitten by suspected animals to rabies and were immunized by purified Vero cell rabies vaccine (PVRV) and Human Rabies immunoglobulin (HRIG) serum. During the years of 2007-2010, six pregnant women by the age range of 22-35 years were admitted in treatment and prevention of rabies center in Pasture institute of Iran, in Tehran. Among them two cases were at first trimester, one at second trimester and three at third trimester of conception. The interval between biting with delivery was 5-265 days (mean 121 days). Conclusion: Results of immunoglobulin illustrate that levels of rabies antibody in maternal sera with the fetus are not equal and uniform but it is proved that baby will find efficient immunity as well with minimum protective level of 0.5 IU/ml in all cases except a newborn whom had been born just 5 days after the mother’s immunization and in a shorter time than the appropriate immunization of the mother who had received her second vaccination courses. Research and Clinical Center for Infertility 2012-03 /pmc/articles/PMC4163280/ /pubmed/25242991 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Fayaz, Ahmad
Simani, Susan
Fallahian, Vida
Eslamifar, Ali
Hazrati, Mahboob
Farahtaj, Firoozeh
Howaizi, Nader
Biglari, Peivand
Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title_full Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title_fullStr Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title_full_unstemmed Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title_short Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
title_sort rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163280/
https://www.ncbi.nlm.nih.gov/pubmed/25242991
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