Cargando…
Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development
Development is a tightly regulated process that involves stem cell self-renewal, differentiation, cell-to-cell communication, apoptosis, and blood vessel formation. These coordinated processes ensure that tissues maintain a size and architecture that is appropriate for normal tissue function. As suc...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163293/ https://www.ncbi.nlm.nih.gov/pubmed/25243094 http://dx.doi.org/10.1155/2014/915725 |
_version_ | 1782334780657893376 |
---|---|
author | Garcia, Cynthia Gutmann, David H. |
author_facet | Garcia, Cynthia Gutmann, David H. |
author_sort | Garcia, Cynthia |
collection | PubMed |
description | Development is a tightly regulated process that involves stem cell self-renewal, differentiation, cell-to-cell communication, apoptosis, and blood vessel formation. These coordinated processes ensure that tissues maintain a size and architecture that is appropriate for normal tissue function. As such, tumors arise when cells acquire genetic mutations that allow them to escape the normal growth constraints. In this regard, the study of tumor predisposition syndromes affords a unique platform to better understand normal development and the process by which normal cells transform into cancers. Herein, we review the processes governing normal brain development, discuss how brain cancer represents a disruption of these normal processes, and highlight insights into both normal development and cancer made possible by the study of tumor predisposition syndromes. |
format | Online Article Text |
id | pubmed-4163293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41632932014-09-21 Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development Garcia, Cynthia Gutmann, David H. Scientifica (Cairo) Review Article Development is a tightly regulated process that involves stem cell self-renewal, differentiation, cell-to-cell communication, apoptosis, and blood vessel formation. These coordinated processes ensure that tissues maintain a size and architecture that is appropriate for normal tissue function. As such, tumors arise when cells acquire genetic mutations that allow them to escape the normal growth constraints. In this regard, the study of tumor predisposition syndromes affords a unique platform to better understand normal development and the process by which normal cells transform into cancers. Herein, we review the processes governing normal brain development, discuss how brain cancer represents a disruption of these normal processes, and highlight insights into both normal development and cancer made possible by the study of tumor predisposition syndromes. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163293/ /pubmed/25243094 http://dx.doi.org/10.1155/2014/915725 Text en Copyright © 2014 C. Garcia and D. H. Gutmann. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Garcia, Cynthia Gutmann, David H. Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title | Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title_full | Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title_fullStr | Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title_full_unstemmed | Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title_short | Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development |
title_sort | using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163293/ https://www.ncbi.nlm.nih.gov/pubmed/25243094 http://dx.doi.org/10.1155/2014/915725 |
work_keys_str_mv | AT garciacynthia usingtheneurofibromatosistumorpredispositionsyndromestounderstandnormalnervoussystemdevelopment AT gutmanndavidh usingtheneurofibromatosistumorpredispositionsyndromestounderstandnormalnervoussystemdevelopment |