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LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population
The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk o...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163406/ https://www.ncbi.nlm.nih.gov/pubmed/25243190 http://dx.doi.org/10.1155/2014/867321 |
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| author | Gopalai, Aroma Agape Lim, Shen-Yang Chua, Jing Yi Tey, Shelisa Lim, Thien Thien Mohamed Ibrahim, Norlinah Tan, Ai Huey Eow, Gaik Bee Abdul Aziz, Zariah Puvanarajah, Santhi Datuk Viswanathan, Shanthi Looi, Irene Lim, Soo Kun Tan, Li Ping Chong, Yip Boon Tan, Chong Tin Zhao, Yi Tan, E. K. Ahmad-Annuar, Azlina |
| author_facet | Gopalai, Aroma Agape Lim, Shen-Yang Chua, Jing Yi Tey, Shelisa Lim, Thien Thien Mohamed Ibrahim, Norlinah Tan, Ai Huey Eow, Gaik Bee Abdul Aziz, Zariah Puvanarajah, Santhi Datuk Viswanathan, Shanthi Looi, Irene Lim, Soo Kun Tan, Li Ping Chong, Yip Boon Tan, Chong Tin Zhao, Yi Tan, E. K. Ahmad-Annuar, Azlina |
| author_sort | Gopalai, Aroma Agape |
| collection | PubMed |
| description | The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies. |
| format | Online Article Text |
| id | pubmed-4163406 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41634062014-09-21 LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population Gopalai, Aroma Agape Lim, Shen-Yang Chua, Jing Yi Tey, Shelisa Lim, Thien Thien Mohamed Ibrahim, Norlinah Tan, Ai Huey Eow, Gaik Bee Abdul Aziz, Zariah Puvanarajah, Santhi Datuk Viswanathan, Shanthi Looi, Irene Lim, Soo Kun Tan, Li Ping Chong, Yip Boon Tan, Chong Tin Zhao, Yi Tan, E. K. Ahmad-Annuar, Azlina Biomed Res Int Research Article The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163406/ /pubmed/25243190 http://dx.doi.org/10.1155/2014/867321 Text en Copyright © 2014 Aroma Agape Gopalai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Gopalai, Aroma Agape Lim, Shen-Yang Chua, Jing Yi Tey, Shelisa Lim, Thien Thien Mohamed Ibrahim, Norlinah Tan, Ai Huey Eow, Gaik Bee Abdul Aziz, Zariah Puvanarajah, Santhi Datuk Viswanathan, Shanthi Looi, Irene Lim, Soo Kun Tan, Li Ping Chong, Yip Boon Tan, Chong Tin Zhao, Yi Tan, E. K. Ahmad-Annuar, Azlina LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title | LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title_full | LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title_fullStr | LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title_full_unstemmed | LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title_short | LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population |
| title_sort | lrrk2 g2385r and r1628p mutations are associated with an increased risk of parkinson's disease in the malaysian population |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163406/ https://www.ncbi.nlm.nih.gov/pubmed/25243190 http://dx.doi.org/10.1155/2014/867321 |
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