Cargando…
Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer,...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163430/ https://www.ncbi.nlm.nih.gov/pubmed/25250334 http://dx.doi.org/10.1155/2014/765207 |
_version_ | 1782334819418505216 |
---|---|
author | Pickl, Julia M. A. Heckmann, Doreen Ratz, Leonie Klauck, Sabine M. Sültmann, Holger |
author_facet | Pickl, Julia M. A. Heckmann, Doreen Ratz, Leonie Klauck, Sabine M. Sültmann, Holger |
author_sort | Pickl, Julia M. A. |
collection | PubMed |
description | The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer, and potentially represent novel targets for diagnosis and therapy. In particular, functional genomic analysis of microRNA (miRNA) and long noncoding RNA (lncRNA) in cancer is likely to contribute insights into tumor development. Here, we compile recent efforts to catalog differential expression of miRNA and lncRNA in prostate cancer and to understand RNA function in tumor progression. We further highlight technologies for molecular characterization of noncoding RNAs and provide an overview of current activities to exploit them for the diagnosis and therapy of this complex tumor. |
format | Online Article Text |
id | pubmed-4163430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41634302014-09-23 Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation Pickl, Julia M. A. Heckmann, Doreen Ratz, Leonie Klauck, Sabine M. Sültmann, Holger Biomed Res Int Review Article The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer, and potentially represent novel targets for diagnosis and therapy. In particular, functional genomic analysis of microRNA (miRNA) and long noncoding RNA (lncRNA) in cancer is likely to contribute insights into tumor development. Here, we compile recent efforts to catalog differential expression of miRNA and lncRNA in prostate cancer and to understand RNA function in tumor progression. We further highlight technologies for molecular characterization of noncoding RNAs and provide an overview of current activities to exploit them for the diagnosis and therapy of this complex tumor. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163430/ /pubmed/25250334 http://dx.doi.org/10.1155/2014/765207 Text en Copyright © 2014 Julia M. A. Pickl et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pickl, Julia M. A. Heckmann, Doreen Ratz, Leonie Klauck, Sabine M. Sültmann, Holger Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title | Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title_full | Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title_fullStr | Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title_full_unstemmed | Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title_short | Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation |
title_sort | novel rna markers in prostate cancer: functional considerations and clinical translation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163430/ https://www.ncbi.nlm.nih.gov/pubmed/25250334 http://dx.doi.org/10.1155/2014/765207 |
work_keys_str_mv | AT pickljuliama novelrnamarkersinprostatecancerfunctionalconsiderationsandclinicaltranslation AT heckmanndoreen novelrnamarkersinprostatecancerfunctionalconsiderationsandclinicaltranslation AT ratzleonie novelrnamarkersinprostatecancerfunctionalconsiderationsandclinicaltranslation AT klaucksabinem novelrnamarkersinprostatecancerfunctionalconsiderationsandclinicaltranslation AT sultmannholger novelrnamarkersinprostatecancerfunctionalconsiderationsandclinicaltranslation |