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Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation

The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer,...

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Detalles Bibliográficos
Autores principales: Pickl, Julia M. A., Heckmann, Doreen, Ratz, Leonie, Klauck, Sabine M., Sültmann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163430/
https://www.ncbi.nlm.nih.gov/pubmed/25250334
http://dx.doi.org/10.1155/2014/765207
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author Pickl, Julia M. A.
Heckmann, Doreen
Ratz, Leonie
Klauck, Sabine M.
Sültmann, Holger
author_facet Pickl, Julia M. A.
Heckmann, Doreen
Ratz, Leonie
Klauck, Sabine M.
Sültmann, Holger
author_sort Pickl, Julia M. A.
collection PubMed
description The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer, and potentially represent novel targets for diagnosis and therapy. In particular, functional genomic analysis of microRNA (miRNA) and long noncoding RNA (lncRNA) in cancer is likely to contribute insights into tumor development. Here, we compile recent efforts to catalog differential expression of miRNA and lncRNA in prostate cancer and to understand RNA function in tumor progression. We further highlight technologies for molecular characterization of noncoding RNAs and provide an overview of current activities to exploit them for the diagnosis and therapy of this complex tumor.
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spelling pubmed-41634302014-09-23 Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation Pickl, Julia M. A. Heckmann, Doreen Ratz, Leonie Klauck, Sabine M. Sültmann, Holger Biomed Res Int Review Article The availability of ultra-high throughput DNA and RNA sequencing technologies in recent years has led to the identification of numerous novel transcripts, whose functions are unknown as yet. Evidence is accumulating that many of these molecules are deregulated in diseases, including prostate cancer, and potentially represent novel targets for diagnosis and therapy. In particular, functional genomic analysis of microRNA (miRNA) and long noncoding RNA (lncRNA) in cancer is likely to contribute insights into tumor development. Here, we compile recent efforts to catalog differential expression of miRNA and lncRNA in prostate cancer and to understand RNA function in tumor progression. We further highlight technologies for molecular characterization of noncoding RNAs and provide an overview of current activities to exploit them for the diagnosis and therapy of this complex tumor. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163430/ /pubmed/25250334 http://dx.doi.org/10.1155/2014/765207 Text en Copyright © 2014 Julia M. A. Pickl et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pickl, Julia M. A.
Heckmann, Doreen
Ratz, Leonie
Klauck, Sabine M.
Sültmann, Holger
Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title_full Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title_fullStr Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title_full_unstemmed Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title_short Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation
title_sort novel rna markers in prostate cancer: functional considerations and clinical translation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163430/
https://www.ncbi.nlm.nih.gov/pubmed/25250334
http://dx.doi.org/10.1155/2014/765207
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