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Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study
Children with rolandic epilepsy (RE) are often associated with cognitive deficits and behavioral problems. Findings from neurophysiological and neuroimaging studies in RE have now demonstrated dysfunction not only in rolandic focus, but also in distant neuronal circuits. Little is known, however, ab...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163434/ https://www.ncbi.nlm.nih.gov/pubmed/25247197 http://dx.doi.org/10.1155/2014/960395 |
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author | Tang, Ye-Lei Ji, Gong-Jun Yu, Yang Wang, Jue Wang, Zhong-Jin Zang, Yu-Feng Liao, Wei Ding, Mei-Ping |
author_facet | Tang, Ye-Lei Ji, Gong-Jun Yu, Yang Wang, Jue Wang, Zhong-Jin Zang, Yu-Feng Liao, Wei Ding, Mei-Ping |
author_sort | Tang, Ye-Lei |
collection | PubMed |
description | Children with rolandic epilepsy (RE) are often associated with cognitive deficits and behavioral problems. Findings from neurophysiological and neuroimaging studies in RE have now demonstrated dysfunction not only in rolandic focus, but also in distant neuronal circuits. Little is known, however, about whether there is distributed abnormal spontaneous brain activity in RE. Using resting-state functional magnetic resonance imaging (RS-fMRI), the present study aimed to determine whether children with RE show abnormal local synchronization during resting state and, if so, whether these changes could be associated with the behavioral/clinical characteristics of RE. Regional homogeneity (ReHo) in children with RE (n = 30) and healthy children (n = 20) was computed on resting-state functional MRI data. In comparison with healthy children, children with RE showed increased ReHo in the central, premotor, and prefrontal regions, while they showed decreased ReHo in bilateral orbitofrontal cortex and temporal pole. In addition, the ReHo value in the left orbitofrontal cortex negatively was corrected with performance intelligence quotient in the children with RE. The aberrant local synchronization, not strictly related to primary site of the typical rolandic focus, indicates the neuropathophysiological mechanism of RE. The study findings may shed new light on the understanding of neural correlation of neuropsychological deficiencies in the children with RE. |
format | Online Article Text |
id | pubmed-4163434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41634342014-09-22 Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study Tang, Ye-Lei Ji, Gong-Jun Yu, Yang Wang, Jue Wang, Zhong-Jin Zang, Yu-Feng Liao, Wei Ding, Mei-Ping Biomed Res Int Research Article Children with rolandic epilepsy (RE) are often associated with cognitive deficits and behavioral problems. Findings from neurophysiological and neuroimaging studies in RE have now demonstrated dysfunction not only in rolandic focus, but also in distant neuronal circuits. Little is known, however, about whether there is distributed abnormal spontaneous brain activity in RE. Using resting-state functional magnetic resonance imaging (RS-fMRI), the present study aimed to determine whether children with RE show abnormal local synchronization during resting state and, if so, whether these changes could be associated with the behavioral/clinical characteristics of RE. Regional homogeneity (ReHo) in children with RE (n = 30) and healthy children (n = 20) was computed on resting-state functional MRI data. In comparison with healthy children, children with RE showed increased ReHo in the central, premotor, and prefrontal regions, while they showed decreased ReHo in bilateral orbitofrontal cortex and temporal pole. In addition, the ReHo value in the left orbitofrontal cortex negatively was corrected with performance intelligence quotient in the children with RE. The aberrant local synchronization, not strictly related to primary site of the typical rolandic focus, indicates the neuropathophysiological mechanism of RE. The study findings may shed new light on the understanding of neural correlation of neuropsychological deficiencies in the children with RE. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163434/ /pubmed/25247197 http://dx.doi.org/10.1155/2014/960395 Text en Copyright © 2014 Ye-Lei Tang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tang, Ye-Lei Ji, Gong-Jun Yu, Yang Wang, Jue Wang, Zhong-Jin Zang, Yu-Feng Liao, Wei Ding, Mei-Ping Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title | Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title_full | Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title_fullStr | Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title_full_unstemmed | Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title_short | Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study |
title_sort | altered regional homogeneity in rolandic epilepsy: a resting-state fmri study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163434/ https://www.ncbi.nlm.nih.gov/pubmed/25247197 http://dx.doi.org/10.1155/2014/960395 |
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