Cargando…

The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans

H. pylori is related to various gastrointestinal diseases. β (2) Microglobulin (β (2)M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β (2)M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β (2)M and H. pylori b...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeniova, Abdullah Özgür, Kucukazman, Metin, Ata, Naim, Dal, Kursat, Kefeli, Ayşe, Başyiğit, Sebahat, Aktaş, Bora, Akın, Kadir Okhan, Nazlıgül, Yaşar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163436/
https://www.ncbi.nlm.nih.gov/pubmed/25243160
http://dx.doi.org/10.1155/2014/615089
_version_ 1782334820852957184
author Yeniova, Abdullah Özgür
Kucukazman, Metin
Ata, Naim
Dal, Kursat
Kefeli, Ayşe
Başyiğit, Sebahat
Aktaş, Bora
Akın, Kadir Okhan
Nazlıgül, Yaşar
author_facet Yeniova, Abdullah Özgür
Kucukazman, Metin
Ata, Naim
Dal, Kursat
Kefeli, Ayşe
Başyiğit, Sebahat
Aktaş, Bora
Akın, Kadir Okhan
Nazlıgül, Yaşar
author_sort Yeniova, Abdullah Özgür
collection PubMed
description H. pylori is related to various gastrointestinal diseases. β (2) Microglobulin (β (2)M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β (2)M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β (2)M and H. pylori bearing CagA strains. Methods. H. pylori status was determined by histopathology of samples taken from stomach. CagA status and β (2)M level were measured from blood samples of patients. Eradication therapy was administered to the patients with H. pylori infection. β (2) Microglobulin levels were measured before and after treatment. Results. 35 (29.2%) H. pylori(−) patients and 85 (70.8%) H. pylori (+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H. pylori infection. The mean serum β (2)M level was 1.83 mg/L in H. pylori (−) group, 1.76 mg/L in H. pylori (+) CagA (−) group, and 1.93 mg/L in H. pylori and CagA (+) group (P > 0.05). Serum β (2)M levels (1.82 versus 1.64 mg/L P < 0.05) were decreased after eradication. Conclusion. H. pylori and CagA status did not affect β (2)M level. Relationship between low grade systematic inflammation and H. pylori should be investigated to find out new predictors for diseases associated with inflammation.
format Online
Article
Text
id pubmed-4163436
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41634362014-09-21 The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans Yeniova, Abdullah Özgür Kucukazman, Metin Ata, Naim Dal, Kursat Kefeli, Ayşe Başyiğit, Sebahat Aktaş, Bora Akın, Kadir Okhan Nazlıgül, Yaşar Biomed Res Int Research Article H. pylori is related to various gastrointestinal diseases. β (2) Microglobulin (β (2)M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β (2)M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β (2)M and H. pylori bearing CagA strains. Methods. H. pylori status was determined by histopathology of samples taken from stomach. CagA status and β (2)M level were measured from blood samples of patients. Eradication therapy was administered to the patients with H. pylori infection. β (2) Microglobulin levels were measured before and after treatment. Results. 35 (29.2%) H. pylori(−) patients and 85 (70.8%) H. pylori (+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H. pylori infection. The mean serum β (2)M level was 1.83 mg/L in H. pylori (−) group, 1.76 mg/L in H. pylori (+) CagA (−) group, and 1.93 mg/L in H. pylori and CagA (+) group (P > 0.05). Serum β (2)M levels (1.82 versus 1.64 mg/L P < 0.05) were decreased after eradication. Conclusion. H. pylori and CagA status did not affect β (2)M level. Relationship between low grade systematic inflammation and H. pylori should be investigated to find out new predictors for diseases associated with inflammation. Hindawi Publishing Corporation 2014 2014-08-27 /pmc/articles/PMC4163436/ /pubmed/25243160 http://dx.doi.org/10.1155/2014/615089 Text en Copyright © 2014 Abdullah Özgür Yeniova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yeniova, Abdullah Özgür
Kucukazman, Metin
Ata, Naim
Dal, Kursat
Kefeli, Ayşe
Başyiğit, Sebahat
Aktaş, Bora
Akın, Kadir Okhan
Nazlıgül, Yaşar
The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title_full The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title_fullStr The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title_full_unstemmed The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title_short The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans
title_sort relationship between helicobacter pylori and beta-2 microglobulin in humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163436/
https://www.ncbi.nlm.nih.gov/pubmed/25243160
http://dx.doi.org/10.1155/2014/615089
work_keys_str_mv AT yeniovaabdullahozgur therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT kucukazmanmetin therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT atanaim therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT dalkursat therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT kefeliayse therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT basyigitsebahat therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT aktasbora therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT akınkadirokhan therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT nazlıgulyasar therelationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT yeniovaabdullahozgur relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT kucukazmanmetin relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT atanaim relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT dalkursat relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT kefeliayse relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT basyigitsebahat relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT aktasbora relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT akınkadirokhan relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans
AT nazlıgulyasar relationshipbetweenhelicobacterpyloriandbeta2microglobulininhumans