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Recent Trends of Polymer Mediated Liposomal Gene Delivery System

Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated g...

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Detalles Bibliográficos
Autores principales: Kundu, Shyamal Kumar, Sharma, Ashish Ranjan, Lee, Sang-Soo, Sharma, Garima, George Priya Doss, C., Yagihara, Shin, Kim, Do-Young, Nam, Ju-Suk, Chakraborty, Chiranjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163454/
https://www.ncbi.nlm.nih.gov/pubmed/25250340
http://dx.doi.org/10.1155/2014/934605
Descripción
Sumario:Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route is offering great promises for gene therapy. This review is an attempt to depict a portrait about the polymer based liposomal gene delivery systems and their future applications. Herein, we have discussed in detail the characteristics of liposome, importance of polymer for liposome formulation, gene delivery, and future direction of liposome based gene delivery as a whole.