Cargando…
The Potential of MicroRNAs in Personalized Medicine against Cancers
MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progressio...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163464/ https://www.ncbi.nlm.nih.gov/pubmed/25243170 http://dx.doi.org/10.1155/2014/642916 |
_version_ | 1782334828846252032 |
---|---|
author | Saumet, Anne Mathelier, Anthony Lecellier, Charles-Henri |
author_facet | Saumet, Anne Mathelier, Anthony Lecellier, Charles-Henri |
author_sort | Saumet, Anne |
collection | PubMed |
description | MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and resistance to chemo/radiotherapies. Thus, microRNAs constitute appealing targets for novel anticancer therapeutic strategies aimed at restoring their expression or function. As microRNAs are present in a variety of human cancer types, microRNA profiles can be used as tumor-specific signatures to detect various cancers (diagnosis), to predict their outcome (prognosis), and to monitor their treatment (theranosis). In this review, we present the different aspects of microRNA biology that make them remarkable molecules in the emerging field of personalized medicine against cancers and provide several examples of their industrial exploitation. |
format | Online Article Text |
id | pubmed-4163464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41634642014-09-21 The Potential of MicroRNAs in Personalized Medicine against Cancers Saumet, Anne Mathelier, Anthony Lecellier, Charles-Henri Biomed Res Int Review Article MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and resistance to chemo/radiotherapies. Thus, microRNAs constitute appealing targets for novel anticancer therapeutic strategies aimed at restoring their expression or function. As microRNAs are present in a variety of human cancer types, microRNA profiles can be used as tumor-specific signatures to detect various cancers (diagnosis), to predict their outcome (prognosis), and to monitor their treatment (theranosis). In this review, we present the different aspects of microRNA biology that make them remarkable molecules in the emerging field of personalized medicine against cancers and provide several examples of their industrial exploitation. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163464/ /pubmed/25243170 http://dx.doi.org/10.1155/2014/642916 Text en Copyright © 2014 Anne Saumet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Saumet, Anne Mathelier, Anthony Lecellier, Charles-Henri The Potential of MicroRNAs in Personalized Medicine against Cancers |
title | The Potential of MicroRNAs in Personalized Medicine against Cancers |
title_full | The Potential of MicroRNAs in Personalized Medicine against Cancers |
title_fullStr | The Potential of MicroRNAs in Personalized Medicine against Cancers |
title_full_unstemmed | The Potential of MicroRNAs in Personalized Medicine against Cancers |
title_short | The Potential of MicroRNAs in Personalized Medicine against Cancers |
title_sort | potential of micrornas in personalized medicine against cancers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163464/ https://www.ncbi.nlm.nih.gov/pubmed/25243170 http://dx.doi.org/10.1155/2014/642916 |
work_keys_str_mv | AT saumetanne thepotentialofmicrornasinpersonalizedmedicineagainstcancers AT mathelieranthony thepotentialofmicrornasinpersonalizedmedicineagainstcancers AT lecelliercharleshenri thepotentialofmicrornasinpersonalizedmedicineagainstcancers AT saumetanne potentialofmicrornasinpersonalizedmedicineagainstcancers AT mathelieranthony potentialofmicrornasinpersonalizedmedicineagainstcancers AT lecelliercharleshenri potentialofmicrornasinpersonalizedmedicineagainstcancers |