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The Potential of MicroRNAs in Personalized Medicine against Cancers

MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progressio...

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Detalles Bibliográficos
Autores principales: Saumet, Anne, Mathelier, Anthony, Lecellier, Charles-Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163464/
https://www.ncbi.nlm.nih.gov/pubmed/25243170
http://dx.doi.org/10.1155/2014/642916
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author Saumet, Anne
Mathelier, Anthony
Lecellier, Charles-Henri
author_facet Saumet, Anne
Mathelier, Anthony
Lecellier, Charles-Henri
author_sort Saumet, Anne
collection PubMed
description MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and resistance to chemo/radiotherapies. Thus, microRNAs constitute appealing targets for novel anticancer therapeutic strategies aimed at restoring their expression or function. As microRNAs are present in a variety of human cancer types, microRNA profiles can be used as tumor-specific signatures to detect various cancers (diagnosis), to predict their outcome (prognosis), and to monitor their treatment (theranosis). In this review, we present the different aspects of microRNA biology that make them remarkable molecules in the emerging field of personalized medicine against cancers and provide several examples of their industrial exploitation.
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spelling pubmed-41634642014-09-21 The Potential of MicroRNAs in Personalized Medicine against Cancers Saumet, Anne Mathelier, Anthony Lecellier, Charles-Henri Biomed Res Int Review Article MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and resistance to chemo/radiotherapies. Thus, microRNAs constitute appealing targets for novel anticancer therapeutic strategies aimed at restoring their expression or function. As microRNAs are present in a variety of human cancer types, microRNA profiles can be used as tumor-specific signatures to detect various cancers (diagnosis), to predict their outcome (prognosis), and to monitor their treatment (theranosis). In this review, we present the different aspects of microRNA biology that make them remarkable molecules in the emerging field of personalized medicine against cancers and provide several examples of their industrial exploitation. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4163464/ /pubmed/25243170 http://dx.doi.org/10.1155/2014/642916 Text en Copyright © 2014 Anne Saumet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Saumet, Anne
Mathelier, Anthony
Lecellier, Charles-Henri
The Potential of MicroRNAs in Personalized Medicine against Cancers
title The Potential of MicroRNAs in Personalized Medicine against Cancers
title_full The Potential of MicroRNAs in Personalized Medicine against Cancers
title_fullStr The Potential of MicroRNAs in Personalized Medicine against Cancers
title_full_unstemmed The Potential of MicroRNAs in Personalized Medicine against Cancers
title_short The Potential of MicroRNAs in Personalized Medicine against Cancers
title_sort potential of micrornas in personalized medicine against cancers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163464/
https://www.ncbi.nlm.nih.gov/pubmed/25243170
http://dx.doi.org/10.1155/2014/642916
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