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An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow–derived macrophages from WT and Ifnb1...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society for Leukocyte Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163629/ https://www.ncbi.nlm.nih.gov/pubmed/25024400 http://dx.doi.org/10.1189/jlb.2A0414-191R |