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TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

BACKGROUND AND OBJECTIVE: Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance. The current treatment protocols involve the use of topoisomerase 1 (TOP1) poisons su...

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Detalles Bibliográficos
Autores principales:	Meisenberg, Cornelia, Ward, Simon E, Schmid, Peter, El-Khamisy, Sherif F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163653/ https://www.ncbi.nlm.nih.gov/pubmed/25232464 http://dx.doi.org/10.4172/1948-5956.1000280

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