Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a

Planar cell polarity (PCP) signaling plays a critical role in tissue morphogenesis. In mammals, disruption of three of the six “core PCP” components results in polarity-dependent defects with rotated cochlear hair cell stereocilia and open neural tube. We recently demonstrated a role of Prickle1, a...

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Detalles Bibliográficos
Autores principales: Liu, Chunqiao, Lin, Chen, Gao, Chun, May-Simera, Helen, Swaroop, Anand, Li, Tiansen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163663/
https://www.ncbi.nlm.nih.gov/pubmed/25190059
http://dx.doi.org/10.1242/bio.20148375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163663/
https://www.ncbi.nlm.nih.gov/pubmed/25190059
http://dx.doi.org/10.1242/bio.20148375

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