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Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study
BACKGROUND: The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163824/ https://www.ncbi.nlm.nih.gov/pubmed/25225559 |
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author | Mogharehabed, Ahmad Birang, Reza Torabinia, Nakisa Nasiri, Saman Behfarnia, Parichehr |
author_facet | Mogharehabed, Ahmad Birang, Reza Torabinia, Nakisa Nasiri, Saman Behfarnia, Parichehr |
author_sort | Mogharehabed, Ahmad |
collection | PubMed |
description | BACKGROUND: The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA). MATERIALS AND METHODS: In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05. RESULTS: The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²). CONCLUSION: The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. However, the difference was not statistically significant. |
format | Online Article Text |
id | pubmed-4163824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41638242014-09-15 Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study Mogharehabed, Ahmad Birang, Reza Torabinia, Nakisa Nasiri, Saman Behfarnia, Parichehr Dent Res J (Isfahan) Original Article BACKGROUND: The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA). MATERIALS AND METHODS: In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05. RESULTS: The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²). CONCLUSION: The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. However, the difference was not statistically significant. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4163824/ /pubmed/25225559 Text en Copyright: © Dental Research Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mogharehabed, Ahmad Birang, Reza Torabinia, Nakisa Nasiri, Saman Behfarnia, Parichehr Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title | Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title_full | Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title_fullStr | Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title_full_unstemmed | Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title_short | Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study |
title_sort | socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: a canine study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163824/ https://www.ncbi.nlm.nih.gov/pubmed/25225559 |
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