Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE(2) production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity

Aspirin has been demonstrated to be effective in inhibiting COX-2 and PGE(2) in Alveolar macrophages (AMs). However, the mechanisms have not been fully understood. In the present study, we found that pretreatment with aspirin inhibited LPS-induced COX-2 and PGE(2) upregulation, IκBα degradation, NFκ...

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Detalles Bibliográficos
Autores principales: Duan, Yuzhong, Chen, Fanglin, Zhang, Anmei, Zhu, Bo, Sun, Jianguo, Xie, Qichao, Chen, Zhengtang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163845/
https://www.ncbi.nlm.nih.gov/pubmed/24209633
http://dx.doi.org/10.5483/BMBRep.2014.47.1.089

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