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The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells
CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to αβ T cells reminiscence of peptide antigen p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163858/ https://www.ncbi.nlm.nih.gov/pubmed/24755556 http://dx.doi.org/10.5483/BMBRep.2014.47.5.077 |
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author | Shin, Jung Hoon Park, Se-Ho |
author_facet | Shin, Jung Hoon Park, Se-Ho |
author_sort | Shin, Jung Hoon |
collection | PubMed |
description | CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to αβ T cells reminiscence of peptide antigen presentation by MHC-I molecules. CD1d is the only member of Group 2 and presents foreign and self lipid antigens to a specialized subset of αβ T cells, NKT cells. NKT cells are involved in diverse immune responses through prompt and massive production of cytokines. CD1d-dependent NKT cells are categorized upon the usage of their T cell receptors. A major subtype of NKT cells (type I) is invariant NKT cells which utilize invariant Vα14-Jα18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alpha chains. Engineered CD1d molecules with modified intracellular trafficking produce either type I or type II NKT cell-defects suggesting the lipid antigens for each subtypes of NKT cells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result of antigen-driven selection, the intracellular metabolic pathways of lipid antigen are a key in forming the functional NKT cell repertoire. [BMB Reports 2014; 47(5): 241-248] |
format | Online Article Text |
id | pubmed-4163858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-41638582014-09-16 The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells Shin, Jung Hoon Park, Se-Ho BMB Rep Articles CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to αβ T cells reminiscence of peptide antigen presentation by MHC-I molecules. CD1d is the only member of Group 2 and presents foreign and self lipid antigens to a specialized subset of αβ T cells, NKT cells. NKT cells are involved in diverse immune responses through prompt and massive production of cytokines. CD1d-dependent NKT cells are categorized upon the usage of their T cell receptors. A major subtype of NKT cells (type I) is invariant NKT cells which utilize invariant Vα14-Jα18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alpha chains. Engineered CD1d molecules with modified intracellular trafficking produce either type I or type II NKT cell-defects suggesting the lipid antigens for each subtypes of NKT cells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result of antigen-driven selection, the intracellular metabolic pathways of lipid antigen are a key in forming the functional NKT cell repertoire. [BMB Reports 2014; 47(5): 241-248] Korean Society for Biochemistry and Molecular Biology 2014-05 /pmc/articles/PMC4163858/ /pubmed/24755556 http://dx.doi.org/10.5483/BMBRep.2014.47.5.077 Text en Copyright © 2014, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Shin, Jung Hoon Park, Se-Ho The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title_full | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title_fullStr | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title_full_unstemmed | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title_short | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells |
title_sort | effect of intracellular trafficking of cd1d on the formation of tcr repertoire of nkt cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163858/ https://www.ncbi.nlm.nih.gov/pubmed/24755556 http://dx.doi.org/10.5483/BMBRep.2014.47.5.077 |
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