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MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN

HER2-overexpressing breast cancers are characterized by frequent distant metastasis and often develop resistance after short-term effective treatment with the monoclonal antibody drug, trastuzumab. Here, we found that the oncogenic miRNA, miR-221, inhibited apoptosis, induced trastuzumab resistance...

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Detalles Bibliográficos
Autores principales:	Ye, Xingming, Bai, Wendong, Zhu, Huayu, Zhang, Xiao, Chen, Ying, Wang, Lei, Yang, Angang, Zhao, Jing, Jia, Lintao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163864/ https://www.ncbi.nlm.nih.gov/pubmed/24286315 http://dx.doi.org/10.5483/BMBRep.2014.47.5.165

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