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Nutlin-3 downregulates p53 phosphorylation on serine(392) and induces apoptosis in hepatocellular carcinoma cells

Drug-resistance and imbalance of apoptotic regulation limit chemotherapy clinical application for the human hepatocellular carcinoma (HCC) treatment. The reactivation of p53 is an attractive therapeutic strategy in cancer with disrupted-p53 function. Nutlin-3, a MDM2 antagonist, has antitumor activi...

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Detalles Bibliográficos
Autores principales:	Shi, Xinli, Liu, Jingli, Ren, Laifeng, Mao, Nan, Tan, Fang, Ding, Nana, Yang, Jing, Li, Mingyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163890/ https://www.ncbi.nlm.nih.gov/pubmed/24286312 http://dx.doi.org/10.5483/BMBRep.2014.47.4.146

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