HDAC3 acts as a negative regulator of angiogenesis

Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Deokbum, Park, Hyunmi, Kim, Youngmi, Kim, Hyuna, Jeoung, Dooil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163891/
https://www.ncbi.nlm.nih.gov/pubmed/24286308
http://dx.doi.org/10.5483/BMBRep.2014.47.4.128
_version_ 1782334884072652800
author Park, Deokbum
Park, Hyunmi
Kim, Youngmi
Kim, Hyuna
Jeoung, Dooil
author_facet Park, Deokbum
Park, Hyunmi
Kim, Youngmi
Kim, Hyuna
Jeoung, Dooil
author_sort Park, Deokbum
collection PubMed
description Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3 enhanced endothelial cell tube formation. HDAC3 negatively regulated tumor-induced angiogenic potential. We show the novel role of HDAC3 as a negative regulator of angiogenesis. [BMB Reports 2014; 47(4): 227-232]
format Online
Article
Text
id pubmed-4163891
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Korean Society for Biochemistry and Molecular Biology
record_format MEDLINE/PubMed
spelling pubmed-41638912014-09-16 HDAC3 acts as a negative regulator of angiogenesis Park, Deokbum Park, Hyunmi Kim, Youngmi Kim, Hyuna Jeoung, Dooil BMB Rep Research Articles Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3 enhanced endothelial cell tube formation. HDAC3 negatively regulated tumor-induced angiogenic potential. We show the novel role of HDAC3 as a negative regulator of angiogenesis. [BMB Reports 2014; 47(4): 227-232] Korean Society for Biochemistry and Molecular Biology 2014-04 /pmc/articles/PMC4163891/ /pubmed/24286308 http://dx.doi.org/10.5483/BMBRep.2014.47.4.128 Text en Copyright © 2014, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Park, Deokbum
Park, Hyunmi
Kim, Youngmi
Kim, Hyuna
Jeoung, Dooil
HDAC3 acts as a negative regulator of angiogenesis
title HDAC3 acts as a negative regulator of angiogenesis
title_full HDAC3 acts as a negative regulator of angiogenesis
title_fullStr HDAC3 acts as a negative regulator of angiogenesis
title_full_unstemmed HDAC3 acts as a negative regulator of angiogenesis
title_short HDAC3 acts as a negative regulator of angiogenesis
title_sort hdac3 acts as a negative regulator of angiogenesis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163891/
https://www.ncbi.nlm.nih.gov/pubmed/24286308
http://dx.doi.org/10.5483/BMBRep.2014.47.4.128
work_keys_str_mv AT parkdeokbum hdac3actsasanegativeregulatorofangiogenesis
AT parkhyunmi hdac3actsasanegativeregulatorofangiogenesis
AT kimyoungmi hdac3actsasanegativeregulatorofangiogenesis
AT kimhyuna hdac3actsasanegativeregulatorofangiogenesis
AT jeoungdooil hdac3actsasanegativeregulatorofangiogenesis

Ejemplares similares