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Women and ARV-based HIV prevention – challenges and opportunities

ARV-based HIV prevention methods available in pill, gel or ring formulations (broadly referred to as microbicides) offer the possibility of protection against HIV for women who find it difficult because they cannot ask their partners to use condoms or even refuse sex. Partial efficacy of ARV-based m...

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Autores principales: Geary, Cynthia W, Bukusi, Elizabeth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163997/
https://www.ncbi.nlm.nih.gov/pubmed/25224621
http://dx.doi.org/10.7448/IAS.17.3.19356
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author Geary, Cynthia W
Bukusi, Elizabeth A
author_facet Geary, Cynthia W
Bukusi, Elizabeth A
author_sort Geary, Cynthia W
collection PubMed
description ARV-based HIV prevention methods available in pill, gel or ring formulations (broadly referred to as microbicides) offer the possibility of protection against HIV for women who find it difficult because they cannot ask their partners to use condoms or even refuse sex. Partial efficacy of ARV-based medications has been demonstrated in a number of clinical trials around the world among various populations, building the evidence that ARV-based technologies will contribute to reducing the AIDS epidemic worldwide. Disappointing results, however, from two trials in sub-Saharan Africa, where poor adherence contributed to study closure due to futility, have raised questions about whether women at the centre of the epidemic are able to effectively use products that require routine use. Also, there are fears by some of risk compensation by decreased condom use because of the availability of microbicides when only partial efficacy has been demonstrated in microbicide trials to date. Of note, sub-analyses of biologic measures of adherence in trials where this was possible have shown a strong correlation between good adherence and efficacy, reinforcing the necessity of good adherence. Research conducted in conjunction with clinical trials and post-trials in advance of possible rollout of ARV-based products have examined social and cultural factors, gender-related and otherwise, influencing adherence and other aspects of women's use of products. These include HIV stigma, women's perception of risk, partner and community influences and the differing needs of women in various stages of life and in different circumstances. It is the purpose of this supplement to give voice to the needs of women who can benefit from woman-initiated methods by presenting research results and commentary to contribute to the global conversation about optimizing women's experience with ARV-based prevention.
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spelling pubmed-41639972014-09-22 Women and ARV-based HIV prevention – challenges and opportunities Geary, Cynthia W Bukusi, Elizabeth A J Int AIDS Soc Women and ARV-based prevention: opportunities and challenges ARV-based HIV prevention methods available in pill, gel or ring formulations (broadly referred to as microbicides) offer the possibility of protection against HIV for women who find it difficult because they cannot ask their partners to use condoms or even refuse sex. Partial efficacy of ARV-based medications has been demonstrated in a number of clinical trials around the world among various populations, building the evidence that ARV-based technologies will contribute to reducing the AIDS epidemic worldwide. Disappointing results, however, from two trials in sub-Saharan Africa, where poor adherence contributed to study closure due to futility, have raised questions about whether women at the centre of the epidemic are able to effectively use products that require routine use. Also, there are fears by some of risk compensation by decreased condom use because of the availability of microbicides when only partial efficacy has been demonstrated in microbicide trials to date. Of note, sub-analyses of biologic measures of adherence in trials where this was possible have shown a strong correlation between good adherence and efficacy, reinforcing the necessity of good adherence. Research conducted in conjunction with clinical trials and post-trials in advance of possible rollout of ARV-based products have examined social and cultural factors, gender-related and otherwise, influencing adherence and other aspects of women's use of products. These include HIV stigma, women's perception of risk, partner and community influences and the differing needs of women in various stages of life and in different circumstances. It is the purpose of this supplement to give voice to the needs of women who can benefit from woman-initiated methods by presenting research results and commentary to contribute to the global conversation about optimizing women's experience with ARV-based prevention. International AIDS Society 2014-09-08 /pmc/articles/PMC4163997/ /pubmed/25224621 http://dx.doi.org/10.7448/IAS.17.3.19356 Text en © 2014 Geary CW and Bukusi EA; licensee International AIDS Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Women and ARV-based prevention: opportunities and challenges
Geary, Cynthia W
Bukusi, Elizabeth A
Women and ARV-based HIV prevention – challenges and opportunities
title Women and ARV-based HIV prevention – challenges and opportunities
title_full Women and ARV-based HIV prevention – challenges and opportunities
title_fullStr Women and ARV-based HIV prevention – challenges and opportunities
title_full_unstemmed Women and ARV-based HIV prevention – challenges and opportunities
title_short Women and ARV-based HIV prevention – challenges and opportunities
title_sort women and arv-based hiv prevention – challenges and opportunities
topic Women and ARV-based prevention: opportunities and challenges
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163997/
https://www.ncbi.nlm.nih.gov/pubmed/25224621
http://dx.doi.org/10.7448/IAS.17.3.19356
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