Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck

In a randomized, double‐blind, placebo‐controlled trial, the mucoadhesive hydrogel MuGard proved to be superior to saline‐bicarbonate rinse in mitigating oral mucositis (OM) symptoms and delaying OM progression. MuGard was safe and well‐tolerated, and favorably affected the rate and incidence of ulc...

Descripción completa

Detalles Bibliográficos
Autores principales: Allison, Ron R., Ambrad, Aaron A., Arshoun, Youssef, Carmel, Richard J., Ciuba, Doug F., Feldman, Elizabeth, Finkelstein, Steven E., Gandhavadi, Ranjini, Heron, Dwight E., Lane, Steven C., Longo, John M., Meakin, Charles, Papadopoulos, Dimitrios, Pruitt, David E., Steinbrenner, Lynn M., Taylor, Michael A., Wisbeck, William M., Yuh, Grace E., Nowotnik, David P., Sonis, Stephen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164024/
https://www.ncbi.nlm.nih.gov/pubmed/24877167
http://dx.doi.org/10.1002/cncr.28553
_version_ 1782334901571289088
author Allison, Ron R.
Ambrad, Aaron A.
Arshoun, Youssef
Carmel, Richard J.
Ciuba, Doug F.
Feldman, Elizabeth
Finkelstein, Steven E.
Gandhavadi, Ranjini
Heron, Dwight E.
Lane, Steven C.
Longo, John M.
Meakin, Charles
Papadopoulos, Dimitrios
Pruitt, David E.
Steinbrenner, Lynn M.
Taylor, Michael A.
Wisbeck, William M.
Yuh, Grace E.
Nowotnik, David P.
Sonis, Stephen T.
author_facet Allison, Ron R.
Ambrad, Aaron A.
Arshoun, Youssef
Carmel, Richard J.
Ciuba, Doug F.
Feldman, Elizabeth
Finkelstein, Steven E.
Gandhavadi, Ranjini
Heron, Dwight E.
Lane, Steven C.
Longo, John M.
Meakin, Charles
Papadopoulos, Dimitrios
Pruitt, David E.
Steinbrenner, Lynn M.
Taylor, Michael A.
Wisbeck, William M.
Yuh, Grace E.
Nowotnik, David P.
Sonis, Stephen T.
author_sort Allison, Ron R.
collection PubMed
description In a randomized, double‐blind, placebo‐controlled trial, the mucoadhesive hydrogel MuGard proved to be superior to saline‐bicarbonate rinse in mitigating oral mucositis (OM) symptoms and delaying OM progression. MuGard was safe and well‐tolerated, and favorably affected the rate and incidence of ulcerative lesions, consistent with the patient‐reported outcomes.
format Online
Article
Text
id pubmed-4164024
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Wiley
record_format MEDLINE/PubMed
spelling pubmed-41640242014-09-22 Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck Allison, Ron R. Ambrad, Aaron A. Arshoun, Youssef Carmel, Richard J. Ciuba, Doug F. Feldman, Elizabeth Finkelstein, Steven E. Gandhavadi, Ranjini Heron, Dwight E. Lane, Steven C. Longo, John M. Meakin, Charles Papadopoulos, Dimitrios Pruitt, David E. Steinbrenner, Lynn M. Taylor, Michael A. Wisbeck, William M. Yuh, Grace E. Nowotnik, David P. Sonis, Stephen T. Cancer Original Articles In a randomized, double‐blind, placebo‐controlled trial, the mucoadhesive hydrogel MuGard proved to be superior to saline‐bicarbonate rinse in mitigating oral mucositis (OM) symptoms and delaying OM progression. MuGard was safe and well‐tolerated, and favorably affected the rate and incidence of ulcerative lesions, consistent with the patient‐reported outcomes. Wiley 2014-02-11 2014-04-22 /pmc/articles/PMC4164024/ /pubmed/24877167 http://dx.doi.org/10.1002/cncr.28553 Text en © 2014 American Cancer Society. Access Pharmaceuticals, Inc. Cancer published by Wiley Periodicals. Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Allison, Ron R.
Ambrad, Aaron A.
Arshoun, Youssef
Carmel, Richard J.
Ciuba, Doug F.
Feldman, Elizabeth
Finkelstein, Steven E.
Gandhavadi, Ranjini
Heron, Dwight E.
Lane, Steven C.
Longo, John M.
Meakin, Charles
Papadopoulos, Dimitrios
Pruitt, David E.
Steinbrenner, Lynn M.
Taylor, Michael A.
Wisbeck, William M.
Yuh, Grace E.
Nowotnik, David P.
Sonis, Stephen T.
Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title_full Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title_fullStr Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title_full_unstemmed Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title_short Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
title_sort multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (mugard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164024/
https://www.ncbi.nlm.nih.gov/pubmed/24877167
http://dx.doi.org/10.1002/cncr.28553
work_keys_str_mv AT allisonronr multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT ambradaarona multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT arshounyoussef multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT carmelrichardj multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT ciubadougf multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT feldmanelizabeth multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT finkelsteinstevene multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT gandhavadiranjini multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT herondwighte multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT lanestevenc multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT longojohnm multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT meakincharles multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT papadopoulosdimitrios multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT pruittdavide multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT steinbrennerlynnm multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT taylormichaela multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT wisbeckwilliamm multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT yuhgracee multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT nowotnikdavidp multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck
AT sonisstephent multiinstitutionalrandomizeddoubleblindplacebocontrolledtrialtoassesstheefficacyofamucoadhesivehydrogelmugardinmitigatingoralmucositissymptomsinpatientsbeingtreatedwithchemoradiationtherapyforcancersoftheheadandneck

Ejemplares similares