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Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma

Radiation therapy (RTx) has been employed as a curative therapy for prostatic adenocarcinoma. RTx-induced sarcomas (RISs) are rare, late adverse events, representing less than 0.2% of all irradiated patients. RISs are more aggressive tumors than prostatic adenocarcinomas. Herein, we present a case w...

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Autores principales: Horiguchi, Hiroto, Takada, Kohichi, Kamihara, Yusuke, Ibata, Soushi, Iyama, Satoshi, Sato, Tsutomu, Hayashi, Tsuyoshi, Miyanishi, Koji, Sato, Yasushi, Takimoto, Rishu, Kobune, Masayoshi, Kobayashi, Ko, Hirayama, Yasuo, Masumori, Naoya, Hasegawa, Tadashi, Kato, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164087/
https://www.ncbi.nlm.nih.gov/pubmed/25232328
http://dx.doi.org/10.1159/000366294
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author Horiguchi, Hiroto
Takada, Kohichi
Kamihara, Yusuke
Ibata, Soushi
Iyama, Satoshi
Sato, Tsutomu
Hayashi, Tsuyoshi
Miyanishi, Koji
Sato, Yasushi
Takimoto, Rishu
Kobune, Masayoshi
Kobayashi, Ko
Hirayama, Yasuo
Masumori, Naoya
Hasegawa, Tadashi
Kato, Junji
author_facet Horiguchi, Hiroto
Takada, Kohichi
Kamihara, Yusuke
Ibata, Soushi
Iyama, Satoshi
Sato, Tsutomu
Hayashi, Tsuyoshi
Miyanishi, Koji
Sato, Yasushi
Takimoto, Rishu
Kobune, Masayoshi
Kobayashi, Ko
Hirayama, Yasuo
Masumori, Naoya
Hasegawa, Tadashi
Kato, Junji
author_sort Horiguchi, Hiroto
collection PubMed
description Radiation therapy (RTx) has been employed as a curative therapy for prostatic adenocarcinoma. RTx-induced sarcomas (RISs) are rare, late adverse events, representing less than 0.2% of all irradiated patients. RISs are more aggressive tumors than prostatic adenocarcinomas. Herein, we present a case with RTx-induced prostatic leiomyosarcoma after permanent brachytherapy for prostatic adenocarcinoma. A 69-year-old male presented with dysuria and gross hematuria. Six years previously, he had been diagnosed with localized prostate cancer and was treated by permanent brachytherapy. Urethroscopy showed stenosis by a tumor at the prostate. Transurethral prostatectomy was performed for a diagnosis. Based on pathological findings, the diagnosis was leiomyosarcoma of the prostate. He was treated with three cycles of neoadjuvant chemotherapy (CTx) that consisted of doxorubicin and ifosfamide (AI), followed by a prostatocystectomy with intrapelvic lymphadenectomy. The tumor extended from the prostate and infiltrated the bladder wall and serosa with lymphatic and venous invasion. The surgical margin was negative, and no residual prostatic adenocarcinoma was observed. The proportion of necrotic tumor cells by neoadjuvant CTx was around 50%. Subsequently, adjuvant CTx was offered, but the patient chose a follow-up without CTx. Local recurrence and lung metastasis were detected by computed tomography 3 months after the surgery. He was treated again with AI. However, CTx was not effective and he died 6 months after the operation. In conclusion, an effective treatment strategy for prostatic sarcoma should be developed in the near future, although the clinical feature of prostatic sarcoma remains unclear due to its rare incidence.
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spelling pubmed-41640872014-09-17 Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma Horiguchi, Hiroto Takada, Kohichi Kamihara, Yusuke Ibata, Soushi Iyama, Satoshi Sato, Tsutomu Hayashi, Tsuyoshi Miyanishi, Koji Sato, Yasushi Takimoto, Rishu Kobune, Masayoshi Kobayashi, Ko Hirayama, Yasuo Masumori, Naoya Hasegawa, Tadashi Kato, Junji Case Rep Oncol Published online: August, 2014 Radiation therapy (RTx) has been employed as a curative therapy for prostatic adenocarcinoma. RTx-induced sarcomas (RISs) are rare, late adverse events, representing less than 0.2% of all irradiated patients. RISs are more aggressive tumors than prostatic adenocarcinomas. Herein, we present a case with RTx-induced prostatic leiomyosarcoma after permanent brachytherapy for prostatic adenocarcinoma. A 69-year-old male presented with dysuria and gross hematuria. Six years previously, he had been diagnosed with localized prostate cancer and was treated by permanent brachytherapy. Urethroscopy showed stenosis by a tumor at the prostate. Transurethral prostatectomy was performed for a diagnosis. Based on pathological findings, the diagnosis was leiomyosarcoma of the prostate. He was treated with three cycles of neoadjuvant chemotherapy (CTx) that consisted of doxorubicin and ifosfamide (AI), followed by a prostatocystectomy with intrapelvic lymphadenectomy. The tumor extended from the prostate and infiltrated the bladder wall and serosa with lymphatic and venous invasion. The surgical margin was negative, and no residual prostatic adenocarcinoma was observed. The proportion of necrotic tumor cells by neoadjuvant CTx was around 50%. Subsequently, adjuvant CTx was offered, but the patient chose a follow-up without CTx. Local recurrence and lung metastasis were detected by computed tomography 3 months after the surgery. He was treated again with AI. However, CTx was not effective and he died 6 months after the operation. In conclusion, an effective treatment strategy for prostatic sarcoma should be developed in the near future, although the clinical feature of prostatic sarcoma remains unclear due to its rare incidence. S. Karger AG 2014-08-16 /pmc/articles/PMC4164087/ /pubmed/25232328 http://dx.doi.org/10.1159/000366294 Text en Copyright © 2014 by S. Karger AG, Basel
spellingShingle Published online: August, 2014
Horiguchi, Hiroto
Takada, Kohichi
Kamihara, Yusuke
Ibata, Soushi
Iyama, Satoshi
Sato, Tsutomu
Hayashi, Tsuyoshi
Miyanishi, Koji
Sato, Yasushi
Takimoto, Rishu
Kobune, Masayoshi
Kobayashi, Ko
Hirayama, Yasuo
Masumori, Naoya
Hasegawa, Tadashi
Kato, Junji
Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title_full Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title_fullStr Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title_full_unstemmed Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title_short Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
title_sort radiation-induced leiomyosarcoma of the prostate after brachytherapy for prostatic adenocarcinoma
topic Published online: August, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164087/
https://www.ncbi.nlm.nih.gov/pubmed/25232328
http://dx.doi.org/10.1159/000366294
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