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Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases
BACKGROUND: Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide. CASE PRESENTATIONS: We report 2 patients who presented with severe ac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164106/ https://www.ncbi.nlm.nih.gov/pubmed/25232325 http://dx.doi.org/10.1159/000365832 |
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author | Baker, Michelle Markman, Maurie Niu, Jiaxin |
author_facet | Baker, Michelle Markman, Maurie Niu, Jiaxin |
author_sort | Baker, Michelle |
collection | PubMed |
description | BACKGROUND: Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide. CASE PRESENTATIONS: We report 2 patients who presented with severe acute hyponatremic encephalopathy after receiving their first cycles of a low-dose cyclophosphamide-containing regimen for breast cancer. In case 1, a 58-year-old female received the combination of docetaxel and cyclophosphamide, and in case 2, a 56-year-old female received the combination of doxorubicin and cyclophosphamide. Both patients recovered after correction of their serum sodium concentration without neurological deficits. Future cycles of chemotherapy were well tolerated without recurrence of hyponatremia after cyclophosphamide was discontinued from the respective regimens. CONCLUSION: Clinicians must always keep in mind that acute hyponatremic encephalopathy can be induced by low-dose cyclophosphamide. |
format | Online Article Text |
id | pubmed-4164106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-41641062014-09-17 Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases Baker, Michelle Markman, Maurie Niu, Jiaxin Case Rep Oncol Published online: July, 2014 BACKGROUND: Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide. CASE PRESENTATIONS: We report 2 patients who presented with severe acute hyponatremic encephalopathy after receiving their first cycles of a low-dose cyclophosphamide-containing regimen for breast cancer. In case 1, a 58-year-old female received the combination of docetaxel and cyclophosphamide, and in case 2, a 56-year-old female received the combination of doxorubicin and cyclophosphamide. Both patients recovered after correction of their serum sodium concentration without neurological deficits. Future cycles of chemotherapy were well tolerated without recurrence of hyponatremia after cyclophosphamide was discontinued from the respective regimens. CONCLUSION: Clinicians must always keep in mind that acute hyponatremic encephalopathy can be induced by low-dose cyclophosphamide. S. Karger AG 2014-07-31 /pmc/articles/PMC4164106/ /pubmed/25232325 http://dx.doi.org/10.1159/000365832 Text en Copyright © 2014 by S. Karger AG, Basel |
spellingShingle | Published online: July, 2014 Baker, Michelle Markman, Maurie Niu, Jiaxin Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title | Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title_full | Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title_fullStr | Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title_full_unstemmed | Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title_short | Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases |
title_sort | cyclophosphamide-induced severe acute hyponatremic encephalopathy in patients with breast cancer: report of two cases |
topic | Published online: July, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164106/ https://www.ncbi.nlm.nih.gov/pubmed/25232325 http://dx.doi.org/10.1159/000365832 |
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