Modulation at Age of Onset in Tunisian Huntington Disease Patients: Implication of New Modifier Genes

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The causative mutation is an expansion of more than 36 CAG repeats in the first exon of IT15 gene. Many studies have shown that the IT15 interacts with several modifier genes to regulate the age at onset (AO) of HD....

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Detalles Bibliográficos
Autores principales: Hmida-Ben Brahim, Dorra, Chourabi, Marwa, Ben Amor, Sana, Harrabi, Imed, Trabelsi, Saoussen, Haddaji-Mastouri, Marwa, Gribaa, Moez, Sassi, Sihem, Gahbiche, Fatma Ezzahra, Lamouchi, Turkia, Mougou-Zereli, Soumaya, Ben Ammou, Sofiane, Saad, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164136/
https://www.ncbi.nlm.nih.gov/pubmed/25254119
http://dx.doi.org/10.1155/2014/210418

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