Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry Quantitation of Urinary [Pyridine-D(4)]4-hydroxy-4-(3-pyridyl)butanoic Acid, a Biomarker of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolic Activation in Smokers

[Image: see text] 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is a potent tobacco-specific lung carcinogen believed to play a key role in the development of lung cancer in smokers. Metabolic activation of NNK to DNA damaging reactive intermediates proceeds via α-hydroxylation pathways. T...

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Detalles Bibliográficos
Autores principales: Jing, Meng, Wang, Yaohua, Upadhyaya, Pramod, Jain, Vipin, Yuan, Jian-Min, Hatsukami, Dorothy K., Hecht, Stephen S., Stepanov, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164226/
https://www.ncbi.nlm.nih.gov/pubmed/25098652
http://dx.doi.org/10.1021/tx5001915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164226/
https://www.ncbi.nlm.nih.gov/pubmed/25098652
http://dx.doi.org/10.1021/tx5001915

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