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Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases
A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, wit...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Gut and Liver
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164250/ https://www.ncbi.nlm.nih.gov/pubmed/25228980 http://dx.doi.org/10.5009/gnl13358 |
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author | Saito, Tamiko Naito, Masafumi Matsumura, Yuki Kita, Hisaaki Kanno, Tomoyo Nakada, Yuki Hamano, Mina Chiba, Miho Maeda, Kosaku Michida, Tomoki Ito, Toshifumi |
author_facet | Saito, Tamiko Naito, Masafumi Matsumura, Yuki Kita, Hisaaki Kanno, Tomoyo Nakada, Yuki Hamano, Mina Chiba, Miho Maeda, Kosaku Michida, Tomoki Ito, Toshifumi |
author_sort | Saito, Tamiko |
collection | PubMed |
description | A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer treatment or medication, including herbal preparations, the liver tumor decreased in size, and the tumor makers diminished. Moreover, after 1 year, the multiple nodules in the bilateral lungs had disappeared. Fifteen months after the first medical examination, transcatheter arterial chemoembolization (TACE) was performed for the residual HCC. Because local relapse was observed on follow-up computed tomography, a second TACE was performed 13 months after the first one. At 4 years after the second TACE (7 years after the initial medical examination), there was no recurrence of primary or metastatic lesions. Spontaneous regression of HCC is very rare, and its mechanism remains unclear. Understanding the underlying mechanism of this rare phenomenon may offer some hope of finding new therapies, even in advanced metastatic cases. |
format | Online Article Text |
id | pubmed-4164250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-41642502014-09-16 Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases Saito, Tamiko Naito, Masafumi Matsumura, Yuki Kita, Hisaaki Kanno, Tomoyo Nakada, Yuki Hamano, Mina Chiba, Miho Maeda, Kosaku Michida, Tomoki Ito, Toshifumi Gut Liver Case Report A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer treatment or medication, including herbal preparations, the liver tumor decreased in size, and the tumor makers diminished. Moreover, after 1 year, the multiple nodules in the bilateral lungs had disappeared. Fifteen months after the first medical examination, transcatheter arterial chemoembolization (TACE) was performed for the residual HCC. Because local relapse was observed on follow-up computed tomography, a second TACE was performed 13 months after the first one. At 4 years after the second TACE (7 years after the initial medical examination), there was no recurrence of primary or metastatic lesions. Spontaneous regression of HCC is very rare, and its mechanism remains unclear. Understanding the underlying mechanism of this rare phenomenon may offer some hope of finding new therapies, even in advanced metastatic cases. Gut and Liver 2014-09 2014-08-18 /pmc/articles/PMC4164250/ /pubmed/25228980 http://dx.doi.org/10.5009/gnl13358 Text en Copyright © 2014 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Saito, Tamiko Naito, Masafumi Matsumura, Yuki Kita, Hisaaki Kanno, Tomoyo Nakada, Yuki Hamano, Mina Chiba, Miho Maeda, Kosaku Michida, Tomoki Ito, Toshifumi Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title | Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title_full | Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title_fullStr | Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title_full_unstemmed | Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title_short | Spontaneous Regression of a Large Hepatocellular Carcinoma with Multiple Lung Metastases |
title_sort | spontaneous regression of a large hepatocellular carcinoma with multiple lung metastases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164250/ https://www.ncbi.nlm.nih.gov/pubmed/25228980 http://dx.doi.org/10.5009/gnl13358 |
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