Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid

In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of...

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Autores principales: Liu, Yao, Liu, Wei, Peng, Qiu-Xian, Peng, Jiang-Li, Yu, Lin-Zhong, Hu, Jian-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164314/
https://www.ncbi.nlm.nih.gov/pubmed/25254052
http://dx.doi.org/10.1155/2014/218383
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author Liu, Yao
Liu, Wei
Peng, Qiu-Xian
Peng, Jiang-Li
Yu, Lin-Zhong
Hu, Jian-Lan
author_facet Liu, Yao
Liu, Wei
Peng, Qiu-Xian
Peng, Jiang-Li
Yu, Lin-Zhong
Hu, Jian-Lan
author_sort Liu, Yao
collection PubMed
description In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.
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spelling pubmed-41643142014-09-24 Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid Liu, Yao Liu, Wei Peng, Qiu-Xian Peng, Jiang-Li Yu, Lin-Zhong Hu, Jian-Lan Evid Based Complement Alternat Med Research Article In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4164314/ /pubmed/25254052 http://dx.doi.org/10.1155/2014/218383 Text en Copyright © 2014 Yao Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yao
Liu, Wei
Peng, Qiu-Xian
Peng, Jiang-Li
Yu, Lin-Zhong
Hu, Jian-Lan
Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title_full Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title_fullStr Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title_full_unstemmed Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title_short Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid
title_sort protective effect of huoxiang zhengqi oral liquid on intestinal mucosal mechanical barrier of rats with postinfectious irritable bowel syndrome induced by acetic acid
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164314/
https://www.ncbi.nlm.nih.gov/pubmed/25254052
http://dx.doi.org/10.1155/2014/218383
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