Cargando…
Chemokine blockade: a new era in the treatment of rheumatoid arthritis?
Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of c...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416447/ https://www.ncbi.nlm.nih.gov/pubmed/15142257 http://dx.doi.org/10.1186/ar1172 |
| _version_ | 1782121413717524480 |
|---|---|
| author | Haringman, Jasper J Tak, Paul P |
| author_facet | Haringman, Jasper J Tak, Paul P |
| author_sort | Haringman, Jasper J |
| collection | PubMed |
| description | Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders. |
| format | Text |
| id | pubmed-416447 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2004 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-4164472004-05-22 Chemokine blockade: a new era in the treatment of rheumatoid arthritis? Haringman, Jasper J Tak, Paul P Arthritis Res Ther Review Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders. BioMed Central 2004 2004-04-01 /pmc/articles/PMC416447/ /pubmed/15142257 http://dx.doi.org/10.1186/ar1172 Text en Copyright © 2004 BioMed Central Ltd |
| spellingShingle | Review Haringman, Jasper J Tak, Paul P Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title | Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title_full | Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title_fullStr | Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title_full_unstemmed | Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title_short | Chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| title_sort | chemokine blockade: a new era in the treatment of rheumatoid arthritis? |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416447/ https://www.ncbi.nlm.nih.gov/pubmed/15142257 http://dx.doi.org/10.1186/ar1172 |
| work_keys_str_mv | AT haringmanjasperj chemokineblockadeanewerainthetreatmentofrheumatoidarthritis AT takpaulp chemokineblockadeanewerainthetreatmentofrheumatoidarthritis |