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Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF
Aim. To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Methods and Results. Two hundred and one Chinese patients were grouped according to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164506/ https://www.ncbi.nlm.nih.gov/pubmed/25250312 http://dx.doi.org/10.1155/2014/106252 |
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author | Lu, Zhigang Wang, Bo Wang, Yunliang Qian, Xueqing Zheng, Wei Wei, Meng |
author_facet | Lu, Zhigang Wang, Bo Wang, Yunliang Qian, Xueqing Zheng, Wei Wei, Meng |
author_sort | Lu, Zhigang |
collection | PubMed |
description | Aim. To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Methods and Results. Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value. Conclusion. NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF. |
format | Online Article Text |
id | pubmed-4164506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41645062014-09-23 Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF Lu, Zhigang Wang, Bo Wang, Yunliang Qian, Xueqing Zheng, Wei Wei, Meng Biomed Res Int Research Article Aim. To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Methods and Results. Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value. Conclusion. NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF. Hindawi Publishing Corporation 2014 2014-08-28 /pmc/articles/PMC4164506/ /pubmed/25250312 http://dx.doi.org/10.1155/2014/106252 Text en Copyright © 2014 Zhigang Lu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lu, Zhigang Wang, Bo Wang, Yunliang Qian, Xueqing Zheng, Wei Wei, Meng Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title | Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title_full | Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title_fullStr | Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title_full_unstemmed | Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title_short | Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF |
title_sort | relationship between ccr and nt-probnp in chinese hf patients, and their correlations with severity of hf |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164506/ https://www.ncbi.nlm.nih.gov/pubmed/25250312 http://dx.doi.org/10.1155/2014/106252 |
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