Prolinks: a database of protein functional linkages derived from coevolution

The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database - Prolinks - that spans 83 organisms and includes 10 million high-confid...

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Autores principales: Bowers, Peter M, Pellegrini, Matteo, Thompson, Mike J, Fierro, Joe, Yeates, Todd O, Eisenberg, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416471/
https://www.ncbi.nlm.nih.gov/pubmed/15128449
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author Bowers, Peter M
Pellegrini, Matteo
Thompson, Mike J
Fierro, Joe
Yeates, Todd O
Eisenberg, David
author_facet Bowers, Peter M
Pellegrini, Matteo
Thompson, Mike J
Fierro, Joe
Yeates, Todd O
Eisenberg, David
author_sort Bowers, Peter M
collection PubMed
description The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database - Prolinks - that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at .
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spelling pubmed-4164712004-05-22 Prolinks: a database of protein functional linkages derived from coevolution Bowers, Peter M Pellegrini, Matteo Thompson, Mike J Fierro, Joe Yeates, Todd O Eisenberg, David Genome Biol Software The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database - Prolinks - that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at . BioMed Central 2004 2004-04-16 /pmc/articles/PMC416471/ /pubmed/15128449 Text en Copyright © 2004 Bowers et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Software
Bowers, Peter M
Pellegrini, Matteo
Thompson, Mike J
Fierro, Joe
Yeates, Todd O
Eisenberg, David
Prolinks: a database of protein functional linkages derived from coevolution
title Prolinks: a database of protein functional linkages derived from coevolution
title_full Prolinks: a database of protein functional linkages derived from coevolution
title_fullStr Prolinks: a database of protein functional linkages derived from coevolution
title_full_unstemmed Prolinks: a database of protein functional linkages derived from coevolution
title_short Prolinks: a database of protein functional linkages derived from coevolution
title_sort prolinks: a database of protein functional linkages derived from coevolution
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416471/
https://www.ncbi.nlm.nih.gov/pubmed/15128449
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