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On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties
BACKGROUND: To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned. METHODS: A set of 18 patients (8 lung, 5 brain, 5 spinal or para-spinal) treated with VMAT in a single fraction of 24Gy were r...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164744/ https://www.ncbi.nlm.nih.gov/pubmed/25193028 http://dx.doi.org/10.1186/1748-717X-9-196 |
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author | Stroom, Joep Vieira, Sandra Mateus, Dalila Greco, Carlo Fogliata, Antonella Nicolini, Giorgia Clivio, Alessandro Vanetti, Eugenio Cozzi, Luca |
author_facet | Stroom, Joep Vieira, Sandra Mateus, Dalila Greco, Carlo Fogliata, Antonella Nicolini, Giorgia Clivio, Alessandro Vanetti, Eugenio Cozzi, Luca |
author_sort | Stroom, Joep |
collection | PubMed |
description | BACKGROUND: To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned. METHODS: A set of 18 patients (8 lung, 5 brain, 5 spinal or para-spinal) treated with VMAT in a single fraction of 24Gy were retrospectively analyzed. All approved plans were re-calculated by applying shifts to the isocentre of ±0.5, ±1, ±1.5, ±2 and ±3 mm along the primary X, Y and Z axes. Dose calculations were performed with the AAA and the Acuros engines. Quantitative analysis of DVH was performed on a total of 36 references (18 patients with AAA, 18 with Acuros) and 1080 re-calculated plans to measure the potential degree of deterioration of the plans according to the simulated errors. RESULTS: The dose to the CTV was essentially not affected by the isocenter shifts in all cases. Concerning PTV, The main impact was observed on the near-to-minimum dose D(99%). No relevant impact was observed on organs at risk in the case of lung patients. In the case of patients treated in the spinal or para-spinal region, the near-to-maximum dose to the spine showed, in the worst scenario, referring to Acuros calculation, a potential average increase of 0.3Gy with a maximum of 1.9Gy (from 10.3 to 12.2 Gy) or 18%. This was partially mitigated to 12% with 1 mm and to 5% with 0.5 mm shifts. CONCLUSIONS: The study showed that shifts in the position of the isocenter as large as 3 mm tend to have modest impacts on the quality of the VMAT plans, scored by means of conventional DVH parameters. From the data shown, the VMAT approach should be considered adequately robust for single fraction SABR. |
format | Online Article Text |
id | pubmed-4164744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41647442014-09-17 On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties Stroom, Joep Vieira, Sandra Mateus, Dalila Greco, Carlo Fogliata, Antonella Nicolini, Giorgia Clivio, Alessandro Vanetti, Eugenio Cozzi, Luca Radiat Oncol Research BACKGROUND: To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned. METHODS: A set of 18 patients (8 lung, 5 brain, 5 spinal or para-spinal) treated with VMAT in a single fraction of 24Gy were retrospectively analyzed. All approved plans were re-calculated by applying shifts to the isocentre of ±0.5, ±1, ±1.5, ±2 and ±3 mm along the primary X, Y and Z axes. Dose calculations were performed with the AAA and the Acuros engines. Quantitative analysis of DVH was performed on a total of 36 references (18 patients with AAA, 18 with Acuros) and 1080 re-calculated plans to measure the potential degree of deterioration of the plans according to the simulated errors. RESULTS: The dose to the CTV was essentially not affected by the isocenter shifts in all cases. Concerning PTV, The main impact was observed on the near-to-minimum dose D(99%). No relevant impact was observed on organs at risk in the case of lung patients. In the case of patients treated in the spinal or para-spinal region, the near-to-maximum dose to the spine showed, in the worst scenario, referring to Acuros calculation, a potential average increase of 0.3Gy with a maximum of 1.9Gy (from 10.3 to 12.2 Gy) or 18%. This was partially mitigated to 12% with 1 mm and to 5% with 0.5 mm shifts. CONCLUSIONS: The study showed that shifts in the position of the isocenter as large as 3 mm tend to have modest impacts on the quality of the VMAT plans, scored by means of conventional DVH parameters. From the data shown, the VMAT approach should be considered adequately robust for single fraction SABR. BioMed Central 2014-09-05 /pmc/articles/PMC4164744/ /pubmed/25193028 http://dx.doi.org/10.1186/1748-717X-9-196 Text en © Stroom et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Stroom, Joep Vieira, Sandra Mateus, Dalila Greco, Carlo Fogliata, Antonella Nicolini, Giorgia Clivio, Alessandro Vanetti, Eugenio Cozzi, Luca On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title | On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title_full | On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title_fullStr | On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title_full_unstemmed | On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title_short | On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties |
title_sort | on the robustness of vmat-sabr treatment plans against isocentre positioning uncertainties |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164744/ https://www.ncbi.nlm.nih.gov/pubmed/25193028 http://dx.doi.org/10.1186/1748-717X-9-196 |
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