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Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality

There is a paucity of data on mineral bone disease in maintenance hemodialysis (MHD) patients from India. This retrospective analysis was undertaken on 858 (males: 599; females: 259) patients from two medical centers on MHD from 1998 to 2010. Age, gender, months on dialysis, hours per session of dia...

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Autores principales: Reddy, Y. N. V., Abraham, G., Nagarajan, P., Matthew, M., Jayaseelan, T., Padma, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165055/
https://www.ncbi.nlm.nih.gov/pubmed/25249720
http://dx.doi.org/10.4103/0971-4065.132988
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author Reddy, Y. N. V.
Abraham, G.
Reddy, Y. N. V.
Nagarajan, P.
Matthew, M.
Jayaseelan, T.
Padma, G.
author_facet Reddy, Y. N. V.
Abraham, G.
Reddy, Y. N. V.
Nagarajan, P.
Matthew, M.
Jayaseelan, T.
Padma, G.
author_sort Reddy, Y. N. V.
collection PubMed
description There is a paucity of data on mineral bone disease in maintenance hemodialysis (MHD) patients from India. This retrospective analysis was undertaken on 858 (males: 599; females: 259) patients from two medical centers on MHD from 1998 to 2010. Age, gender, months on dialysis, hours per session of dialysis, hemoglobin, serum calcium, inorganic phosphorus, intact parathyroid hormone (iPTH), urine output, erythropoietin dosage per week, blood sugar, blood pressure, urea reduction rate, gain in fluid and fluid removed per session, serum albumin, alkaline phosphatase, vitamin D level, supplemental vitamin D and use of phosphate binder for therapy were documented. Overall, 191 patients died (22%) during the observation period. There was an 86% patient survival rate at 1 year on dialysis and an overall predicted 3-year survival rate of 78%. A relatively higher iPTH (P = 0.012), a need for vitamin D supplementation (P = 0.003), less hours on dialysis per session (P = 0.046) and a non-vegetarian diet (P = 0.022) were significantly associated with mortality.
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spelling pubmed-41650552014-09-23 Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality Reddy, Y. N. V. Abraham, G. Reddy, Y. N. V. Nagarajan, P. Matthew, M. Jayaseelan, T. Padma, G. Indian J Nephrol Original Article There is a paucity of data on mineral bone disease in maintenance hemodialysis (MHD) patients from India. This retrospective analysis was undertaken on 858 (males: 599; females: 259) patients from two medical centers on MHD from 1998 to 2010. Age, gender, months on dialysis, hours per session of dialysis, hemoglobin, serum calcium, inorganic phosphorus, intact parathyroid hormone (iPTH), urine output, erythropoietin dosage per week, blood sugar, blood pressure, urea reduction rate, gain in fluid and fluid removed per session, serum albumin, alkaline phosphatase, vitamin D level, supplemental vitamin D and use of phosphate binder for therapy were documented. Overall, 191 patients died (22%) during the observation period. There was an 86% patient survival rate at 1 year on dialysis and an overall predicted 3-year survival rate of 78%. A relatively higher iPTH (P = 0.012), a need for vitamin D supplementation (P = 0.003), less hours on dialysis per session (P = 0.046) and a non-vegetarian diet (P = 0.022) were significantly associated with mortality. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4165055/ /pubmed/25249720 http://dx.doi.org/10.4103/0971-4065.132988 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Reddy, Y. N. V.
Abraham, G.
Reddy, Y. N. V.
Nagarajan, P.
Matthew, M.
Jayaseelan, T.
Padma, G.
Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title_full Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title_fullStr Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title_full_unstemmed Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title_short Mineral bone disease in maintenance hemodialysis patients: Association with morbidity and mortality
title_sort mineral bone disease in maintenance hemodialysis patients: association with morbidity and mortality
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165055/
https://www.ncbi.nlm.nih.gov/pubmed/25249720
http://dx.doi.org/10.4103/0971-4065.132988
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